Related Experiment Video

Updated: Oct 16, 2025

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

3.8K

Dopamine, Serotonin, and Structure/Function Brain Defects as Biological Bases for Treatment Response in Delusional

Armand Guàrdia1, Alexandre González-Rodríguez1, Mary V Seeman2

  • 1Department of Mental Health, Mutua Terrassa University Hospital, University of Barcelona, 08221 Terrassa, Spain.

Behavioral Sciences (Basel, Switzerland)
|October 22, 2021
PubMed

Insights

Treatment response in delusional disorder involves more than dopamine. This review highlights dopaminergic, serotonergic, and brain structure factors influencing treatment outcomes.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Antipsychotic efficacy is primarily linked to dopamine D2/D3 receptor blockade.
  • Variability in patient treatment response necessitates exploring additional biological underpinnings.

Purpose of the Study:

  • To systematically review existing literature on treatment response in delusional disorder (DD).
  • To identify biological factors contributing to treatment response in DD.
  • To inform future research directions for understanding DD's biological basis.

Main Methods:

  • Systematic literature search of ClinicalTrials.gov, PubMed, and Scopus (1999-2021).
  • Inclusion of studies diagnosing DD per ICD or DSM criteria and exploring biological treatment response mechanisms.
  • Analysis of case reports, case series, and cohort studies.

Main Results:

  • Dopaminergic dysfunction, supported by biochemical and genetic data, is implicated.
  • Serotonergic system involvement is suggested by drug agonism/antagonism.
  • Impairments in brain structure and function, particularly in temporal and parietal lobes, are crucial.

Conclusions:

  • Delusional disorder treatment response is multifactorial, involving dopaminergic, serotonergic, and neuroanatomical systems.
  • Further high-quality research is essential to elucidate these biological bases.
  • Understanding these factors will aid clinicians in optimizing DD treatment strategies.
Keywords:
delusional disorderdopamineneurobiologypsychosisserotonin

More Related Videos

Developing a Rat Model for Bipolar Disorder04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

639
Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology07:25

Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology

Published on: March 27, 2018

8.7K

Related Concept Videos

Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
182
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
1.2K
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
426
Theoretical Approaches to Psychological Disorder01:29

Theoretical Approaches to Psychological Disorder

The development of psychological disorders, which are characterized by deviant, maladaptive, and personally distressing behaviors, has been explored through several theoretical approaches.
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
377
Introduction to Biological Bases of Psychology01:30

Introduction to Biological Bases of Psychology

Biopsychology serves as a vital bridge connecting the intricate domains of biology and psychology, shedding light on how biological systems influence psychological phenomena. This field scrutinizes the biological substrates of behavior and mental processes, emphasizing the nervous system along with the roles of neurotransmitters, hormones, and genetics. It also incorporates evolutionary perspectives to explain the adaptive nature of mental functions.
The nervous system, the cornerstone of...
3.7K
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
182