Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview01:19

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

1.0K
In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A composite lateral flow test substrate by capillary deposition of cellulose on synthetic paper.

RSC advances·2026
Same author

OSTE Superhydrophobic Synthetic Paper (SUSP) with Superior Plastron Stability by Capillary Effect.

Small methods·2026
Same author

Fabrication of Paper Microfluidic Chips via Wax Soft Lithography.

Micromachines·2026
Same author

Advances in Nanohybrid Hydrogels for Wound Healing: From Functional Mechanisms to Translational Prospects.

Gels (Basel, Switzerland)·2025
Same author

Fast capillary flow on μPADs with hollow channels packaged by a thermal contraction tube.

Lab on a chip·2025
Same author

Parylene-C Modified OSTE Molds for PDMS Microfluidic Chip Fabrication and Applications in Plasma Separation and Polymorphic Crystallization.

Biosensors·2025
Same journal

A Coumarin-Based Probe for Sequential ON-OFF-ON Detection of Cu<sup>2+</sup> and Biothiols: Naked-Eye Detection, Smartphone RGB Readout and In Vivo Imaging.

Biosensors·2026
Same journal

Electropolymerized Molecularly Imprinted Polymers Supported on Carbon-Based Materials for (Bio)sensing: Direct and Indirect Detection Strategies.

Biosensors·2026
Same journal

Progress in (Photo)electrochemical Biosensors for the Detection of Amyloid-Beta Oligomer.

Biosensors·2026
Same journal

Design and Simulation of Lamotrigine Intermittent Release from a Subcutaneous Implant with an Enzymatic Biosensor Based on Clinical Data.

Biosensors·2026
Same journal

Prediction of Chronic Kidney Disease Based on Simulated Serum Analysis by Vibrational Spectroscopy.

Biosensors·2026
Same journal

AI/ML-Assisted SERS Biosensing for Biomolecular Detection: From Direct Spectral Response to Integrated Diagnostic Systems.

Biosensors·2026
See all related articles

Related Experiment Video

Updated: Oct 16, 2025

Implementation of a Hyperbolic Vortex Plasma Reactor for the Removal of Micropollutants in Water
06:35

Implementation of a Hyperbolic Vortex Plasma Reactor for the Removal of Micropollutants in Water

Published on: July 25, 2025

407

High-Performance Passive Plasma Separation on OSTE Pillar Forest.

Zhiqing Xiao1, Lexin Sun1, Yuqian Yang1

  • 1Department of Biomedical Engineering, Shantou Univeristy, Shantou 515063, China.

Biosensors
|October 22, 2021
PubMed
Summary
This summary is machine-generated.

A new microfluidic device efficiently separates plasma from whole blood using a filtration membrane and off-stoichiometry thiol-ene (OSTE) pillars. This high-performance device is ideal for developing advanced lateral flow tests.

Keywords:
OSTEfiltration membranelateral flow testspillar forestplasma separationprotein recovery rateseparation yield

More Related Videos

An Atmospheric Pressure Plasma Setup to Investigate the Reactive Species Formation
08:36

An Atmospheric Pressure Plasma Setup to Investigate the Reactive Species Formation

Published on: November 3, 2016

10.1K
Primary Clarification of CHO Harvested Cell Culture Fluid using an Acoustic Separator
07:06

Primary Clarification of CHO Harvested Cell Culture Fluid using an Acoustic Separator

Published on: May 14, 2020

5.3K

Related Experiment Videos

Last Updated: Oct 16, 2025

Implementation of a Hyperbolic Vortex Plasma Reactor for the Removal of Micropollutants in Water
06:35

Implementation of a Hyperbolic Vortex Plasma Reactor for the Removal of Micropollutants in Water

Published on: July 25, 2025

407
An Atmospheric Pressure Plasma Setup to Investigate the Reactive Species Formation
08:36

An Atmospheric Pressure Plasma Setup to Investigate the Reactive Species Formation

Published on: November 3, 2016

10.1K
Primary Clarification of CHO Harvested Cell Culture Fluid using an Acoustic Separator
07:06

Primary Clarification of CHO Harvested Cell Culture Fluid using an Acoustic Separator

Published on: May 14, 2020

5.3K

Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Materials Science

Background:

  • Plasma separation is crucial for whole blood analysis in lateral flow tests.
  • Existing methods face challenges in efficiency and purity.
  • Developing passive, high-performance separation devices is a key research area.

Purpose of the Study:

  • To develop a passive microfluidic device for efficient and high-purity plasma separation from whole blood.
  • To integrate a blood filtration membrane with an off-stoichiometry thiol-ene (OSTE) pillar forest for capillary pumping.
  • To evaluate the performance of the device in terms of speed, yield, and protein recovery.

Main Methods:

  • Fabrication of OSTE pillar forest using double replica molding of a laser-cut polymethylmethacrylate (PMMA) mold.
  • Integration of a blood filtration membrane with the OSTE pillar forest.
  • Utilizing capillary action for plasma propulsion and separation.
  • Characterization of plasma separation efficiency, speed, and protein recovery.

Main Results:

  • The device processed 45 μL of whole blood in 72 seconds.
  • Achieved a high plasma separation yield of 60.0%.
  • Demonstrated a protein recovery rate of 85.5%, comparable to state-of-the-art technologies.

Conclusions:

  • The developed passive microfluidic device offers high-performance plasma separation.
  • The device integrates a filtration membrane and OSTE pillar forest for efficient blood processing.
  • This technology holds significant potential for advancing lateral flow tests for biomarker detection.