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Novel Micro-Nano Optoelectronic Biosensor for Label-Free Real-Time Biofilm Monitoring.

Giuseppe Brunetti1, Donato Conteduca1,2, Mario Nicola Armenise1

  • 1Optoelectronics Laboratory, Department of Electrical and Information Engineering, Polytechnic University of Bari, 70125 Bari, Italy.

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|October 22, 2021
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Summary

A new optoelectronic device monitors bacterial biofilm development using optical and electrical signals. This technology aids in understanding antibiotic resistance and evaluating treatment effectiveness against biofilms.

Keywords:
antimicrobial resistancebacteria biofilmbiosensingoptoelectronic device

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Area of Science:

  • Biomedical Engineering
  • Microbiology
  • Optoelectronics

Background:

  • Antimicrobial Resistance (AMR) is a growing global health threat, exacerbated by antibiotic-inactivating bacterial biofilms.
  • Current methods for studying biofilm formation and antibiotic efficacy lack real-time, non-destructive capabilities.

Purpose of the Study:

  • To develop a novel optoelectronic device for real-time monitoring of bacterial biofilm evolution.
  • To assess the device's capability in analyzing antibiotic effectiveness against biofilms.

Main Methods:

  • Design of a dual array of interdigitated micro- and nanoelectrodes for simultaneous optical and electrical measurements.
  • Utilizing Guided Mode Resonance (GMR) for optical detection of bacterial interactions and biofilm formation.
  • Employing electrical measurements to assess bacterial metabolic state and biofilm destruction.

Main Results:

  • The optical response detected a 0.9 nm wavelength shift due to bacterial presence, enabling high-resolution analysis of early biofilm development.
  • Electrical measurements indicated a 330 nA current change upon biofilm destruction (15 µm thickness), correlating with antibiotic efficacy.
  • The device demonstrated label-free, real-time monitoring of biofilm maturation and antibiotic treatment.

Conclusions:

  • The proposed optoelectronic device offers a promising non-destructive, label-free approach for studying bacterial biofilms.
  • This technology can significantly advance the understanding of antimicrobial resistance and the development of new therapeutic strategies.