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Multiplexed Near-Field Optical Trapping Exploiting Anapole States.

Donato Conteduca1, Giuseppe Brunetti2, Isabel Barth1

  • 1School of Physics, Engineering and Technology, University of York, Heslington, York YO10 5DD, United Kingdom.

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Researchers developed a novel resonant metasurface for large-scale multiplexed optical trapping of nanoparticles. This breakthrough enables parallel manipulation of numerous nanoscale bioparticles, advancing biological heterogeneity studies.

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Area of Science:

  • Nanophotonics
  • Biophysics
  • Optical Engineering

Background:

  • Optical tweezers are crucial for high-accuracy bioscience research, primarily focusing on individual particle manipulation.
  • Studying biological heterogeneity necessitates methods for analyzing variations within populations.
  • Current optical trapping methods face challenges in multiplexing at the nanoscale.

Purpose of the Study:

  • To demonstrate a resonant metasurface capable of high-throughput, parallel optical trapping of nanoscale particles.
  • To enable large-scale multiplexed optical trapping for studying biological heterogeneity.
  • To overcome limitations in nanoscale multiplexing for optical tweezers.

Main Methods:

  • Experimental demonstration of a resonant metasurface utilizing an anapole state for enhanced light-matter interaction.
  • Utilizing the anapole state's angle tolerance for efficient excitation with focused light beams.
  • Applying the metasurface for trapping hundreds of 100 nm polystyrene beads and multiplexed trapping of lipid vesicles.

Main Results:

  • Successful parallel trapping of hundreds of 100 nm polystyrene beads over 10 minutes.
  • Demonstrated multiplexed trapping of lipid vesicles using moderate optical intensity (<250 μW/μm²).
  • The metasurface enables high-density nanoparticle trapping via near-field enhancement.

Conclusions:

  • The developed resonant metasurface significantly advances large-scale multiplexed optical trapping capabilities.
  • This technology opens new avenues for investigating the heterogeneity of biological systems at the nanoscale.
  • Enables detailed studies of viruses, extracellular vesicles, and other nanoscale bioparticles.