Research Progress in Anti-Inflammatory Bioactive Substances Derived from Marine Microorganisms, Sponges, Algae, and...

Area of Science:

• Marine natural products chemistry
• Pharmacology
• Drug discovery

Background:

• Chronic inflammation is linked to disease development.
• Marine organisms are a rich source of unique bioactive compounds.
• Marine-derived substances show significant anti-inflammatory potential.

Purpose of the Study:

• To review marine-organism-derived anti-inflammatory metabolites.
• To summarize structures, sources, and activities of these compounds.
• To provide a reference for developing new anti-inflammatory drugs.

Main Methods:

• Literature review of marine bioactive substances.
• Analysis of 71 substances reported between 2015-2020.
• Focus on structures, species sources, and anti-inflammatory evaluation.

Main Results:

• 71 anti-inflammatory bioactive substances from marine organisms were identified.
• Structures of 65 compounds were detailed.
• Various marine sources including bacteria, fungi, sponges, algae, and coral were investigated.

Conclusions:

• Marine organisms offer a diverse pool of anti-inflammatory agents.
• Further research can accelerate the development of marine-derived anti-inflammatory drugs.
• These compounds represent promising leads for novel therapeutic strategies.