Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of anti-tuberculosis drugs on the pharmacokinetics and pharmacodynamics of novel antidiabetic drugs: A scoping review.

Pulmonology·2026
Same author

A multinational Delphi consensus on tuberculosis screening of migrants in Europe.

ERJ open research·2025
Same author

European guidelines for the management of tuberculosis screening procedures in migrants: A systematic review.

Pulmonology·2025
Same author

Expert perspectives on tuberculosis screening procedures for migrants.

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia·2025
Same author

Special Issue on Cancer Smart Nanomedicine.

Cancers·2023
Same author

Special Issue on Drug-Membrane Interactions Volume II.

Membranes·2022

Related Experiment Video

Updated: Oct 16, 2025

Detection of Detergent-sensitive Interactions Between Membrane Proteins
10:09

Detection of Detergent-sensitive Interactions Between Membrane Proteins

Published on: March 7, 2018

6.1K

Special Issue on Drug-Membrane Interactions.

Marina Pinheiro1

  • 1LAQV-REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, P-4050-313 Porto, Portugal.

Membranes
|October 22, 2021
PubMed
Summary

Drug-membrane interactions are crucial for drug delivery and efficacy. Understanding these initial interactions is key to developing more effective therapeutics.

Area of Science:

  • Pharmacology
  • Biophysics
  • Materials Science

Background:

  • Drug-membrane interactions are fundamental to pharmacokinetics and pharmacodynamics.
  • These interactions influence drug absorption, distribution, metabolism, and excretion (ADME).
  • The cell membrane acts as a primary barrier and interface for drug action.

Discussion:

  • The initial contact between a drug and biological membranes dictates its fate.
  • Factors such as drug lipophilicity, charge, and membrane composition modulate these interactions.
  • Understanding these early events is critical for predicting drug behavior in vivo.

Key Insights:

  • Immediate drug-membrane interactions occur regardless of administration route or target site.
  • Membrane permeability and drug partitioning are initial determinants of bioavailability.

More Related Videos

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
12:18

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions

Published on: August 3, 2021

3.7K
Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy
10:49

Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy

Published on: March 5, 2017

13.5K

Related Experiment Videos

Last Updated: Oct 16, 2025

Detection of Detergent-sensitive Interactions Between Membrane Proteins
10:09

Detection of Detergent-sensitive Interactions Between Membrane Proteins

Published on: March 7, 2018

6.1K
Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
12:18

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions

Published on: August 3, 2021

3.7K
Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy
10:49

Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy

Published on: March 5, 2017

13.5K
  • The biophysical properties of both the drug and the membrane are critical.

    • Outlook:

    • Further research into drug-membrane dynamics can optimize drug design and delivery systems.
    • Advanced computational and experimental models are needed to fully elucidate these interactions.
    • Targeting specific membrane components could enhance therapeutic efficacy and reduce side effects.