Related Experiment Video
Updated: Oct 16, 2025
08:27
Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury
Published on: May 21, 2018
11.1K
Exosomes in chronic respiratory diseases.
Beatrice Purghè1, Marcello Manfredi1, Beatrice Ragnoli2
1Department of Translational Medicine, University of Piemonte Orientale, 28100 Novara, Italy; Center for Translational Research on Allergic and Autoimmune Diseases (CAAD), University of Piemonte Orientale, 28100 Novara, Italy.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|October 22, 2021
Summary
Exosomes, tiny vesicles involved in cell communication, are key players in inflammation. This review explores their potential as biomarkers and therapeutics for chronic respiratory diseases like asthma and COPD.
Area of Science:
- Cell Biology
- Pulmonary Medicine
- Biomarkers
Background:
- Exosomes are nano-sized vesicles mediating intercellular communication.
- These extracellular vesicles play a significant role in inflammatory processes.
- Chronic respiratory diseases share underlying dysregulated inflammation, but distinct mechanisms remain unclear.
Purpose of the Study:
- To review studies on exosomes in airway diseases.
- To discuss exosome isolation and characterization techniques.
- To explore the potential of exosomes as biomarkers and therapeutics for chronic respiratory disorders.
Main Methods:
- Literature review of studies on exosomes from body fluids of patients with airway diseases.
- Description of common exosome isolation techniques.
- Description of common exosome characterization methods.
Main Results:
- Exosomes are implicated in the inflammatory processes of chronic respiratory diseases.
- Various studies have investigated exosomes in conditions such as asthma, COPD, alpha-1 antitrypsin deficiency, and idiopathic pulmonary fibrosis.
- Standardized methods for exosome isolation and characterization are crucial for reliable research.
Conclusions:
- Exosomes show promise as biomarkers and therapeutic targets for chronic respiratory diseases.
- Further research is necessary to elucidate the precise functional role of exosomes in these conditions.
- Understanding the link between exosome function and disease phenotypes is critical for clinical applications.
Related Concept Videos
01:36Overview of Exosomes
2.9K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.9K
01:22Chronic Obstructive Pulmonary Disease
1.5K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.5K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
3.3K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
3.3K
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
3.1K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
3.1K
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
3.0K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
3.0K
01:20COPD: Pathogenesis and Clinical Features
690
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
690