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Updated: Oct 16, 2025
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
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Determinants of left ventricular structure, filling and long axis function in systemic sclerosis
Roger E Peverill1, Gene-Siew Ngian2,3, Catherine Mylrea1
1Department of Medicine (School of Clinical Sciences at Monash Health), Monash Cardiovascular Research Centre, Monash Heart, Monash University and Monash Health, Clayton, Victoria, Australia.
Plos One
|October 22, 2021
Summary
Systemic sclerosis (SSc) affects left ventricular (LV) structure and function. Factors like age, sex, and body size influence LV measurements in SSc patients, necessitating adjustments for accurate assessment.
Area of Science:
- Cardiology
- Rheumatology
- Echocardiography
Background:
- Systemic sclerosis (SSc) is associated with left ventricular (LV) abnormalities, but findings are inconsistent.
- Previous studies may be confounded by factors like body surface area (BSA), sex, age, and disease characteristics.
Purpose of the Study:
- To identify factors confounding previous analyses of LV structure and function in SSc patients.
- To investigate the influence of BSA, sex, age, heart rate, blood pressure, disease duration (DD), disease type, and interstitial lung disease (ILD) on LV variables.
Main Methods:
- Echocardiography was performed on 100 SSc patients with normal LV ejection fraction (LVEF) ≥50%.
- Measurements included LV dimensions, wall thickness, transmitral Doppler parameters, and LV long-axis velocities.
- Multivariate analyses assessed correlations between LV variables and confounding factors.
Main Results:
- LV structure (SWT, LVEDD) correlated with BSA, age, sex, and disease type.
- LV filling (E/A) and long-axis function (s', e') correlated with age and heart rate.
- Interstitial lung disease (ILD) did not predict any LV variables.
Conclusions:
- Sex, body size, age, and disease type are associated with LV structure in SSc.
- Age and heart rate influence LV filling and function.
- Adjusting for these factors is crucial for understanding SSc's impact on the left ventricle.
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