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Related Experiment Video

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STAT3 Activation in Psoriasis and Cancers.

Megumi Kishimoto1, Mayumi Komine1, Miho Sashikawa-Kimura1

  • 1Department of Dermatology, Jichi Medical University, Shimotsuke-shi 329-0498, Tochigi, Japan.

Diagnostics (Basel, Switzerland)
|October 23, 2021
PubMed
Summary

Psoriasis patients do not show a predisposition to signal transducer and activator of transcription (STAT)3 activation in common cancers. STAT3 activation appears to be regulated by individual disease or microenvironment factors.

Keywords:
STAT3cancerimmunohistochemistrypsoriasis

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Area of Science:

  • Oncology
  • Immunodermatology

Background:

  • Signal transducer and activator of transcription (STAT)3 activation is implicated in numerous cancers and psoriasis.
  • STAT3 activation is observed in skin lesions of psoriasis, a chronic inflammatory skin condition.

Purpose of the Study:

  • To investigate if patients with psoriasis exhibit a higher predisposition to STAT3 activation in cancerous tissues.
  • To compare STAT3 activation levels in cancer cells between psoriasis patients and a control group.

Main Methods:

  • Immunohistochemistry was used to detect phosphorylated STAT3 in tumor cells.
  • The study included patients with a history of gastric, lung, and head and neck cancers who also have psoriasis.
  • Cancer patients with and without psoriasis were compared for STAT3 activation.

Main Results:

  • No significant difference in STAT3 activation was found in gastric, lung, or head and neck cancers between psoriasis patients and controls.
  • The findings suggest STAT3 activation is not inherently higher in cancer patients with psoriasis.

Conclusions:

  • Psoriasis patients do not appear to have a predisposition to STAT3 activation in these cancer types.
  • STAT3 activation is likely regulated independently by the specific disorder and cellular microenvironment in cancer and psoriasis.