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Related Experiment Video

Updated: Oct 16, 2025

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

Amputation for Extremity Sarcoma: Indications and Outcomes.

Maya Kirilova^1,2, Alexander Klein^1,2, Lars H Lindner^2,3

¹Musculoskeletal Oncology, Department of Orthopaedics and Trauma Surgery, University Hospital, Ludwig-Maximilians-University Munich, D-81377 Munich, Germany.

|October 23, 2021

Summary

This summary is machine-generated.

Amputation for sarcoma, whether primary or after failed limb salvage surgery (LSS), shows similar oncological outcomes. However, amputation generally indicates worse overall survival compared to LSS.

Keywords:

amputation local recurrence prognosis sarcoma surgery survival

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A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies

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Published on: July 28, 2020

Area of Science:

Orthopedic Oncology
Surgical Oncology

Background:

Sarcomas are rare malignant tumors affecting soft tissues and bone.
Limb salvage surgery (LSS) is the standard treatment for sarcomas.
Amputation remains an option, particularly for local recurrence or complications post-LSS.

Purpose of the Study:

To evaluate oncological outcomes in patients undergoing amputation for sarcoma.
To compare outcomes of primary amputation versus secondary amputation after failed LSS.

Main Methods:

Retrospective review of patients who underwent amputation for sarcoma.
Comparison of two groups: primary amputations (n=120) and secondary amputations after failed LSS (n=29).
Analysis of local recurrence-free survival (LRFS) and overall survival (OS) as primary endpoints.

Main Results:

Five-year LRFS was 84%; 16% of patients experienced local recurrence.
Metastatic disease developed in 28% of patients; five-year OS was 44%.
OS was comparable between primary and secondary amputation groups. Secondary amputation due to complications showed better OS than due to recurrence/margins.

Conclusions:

Amputation for sarcoma is associated with worse oncological outcomes, specifically overall survival, compared to LSS.
Primary and secondary amputations after failed LSS yield similar oncological results.
Amputation is a critical consideration in sarcoma management, especially in cases of recurrence or complications.