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Live Birth Rates after Active Immunization with Partner Lymphocytes.

Veronika Günther1,2,3,4, Ibrahim Alkatout1, Lisa Meyerholz1

  • 1Department of Obstetrics and Gynecology, University Hospitals Schleswig-Holstein, Campus Kiel, Arnold-Heller-Straße 3 (House C), 24105 Kiel, Germany.

Biomedicines
|October 23, 2021
PubMed
Summary

Lymphocyte immunotherapy (LIT) using paternal cells improved live birth rates in women with recurrent miscarriage (RM) and recurrent implantation failure (RIF). Success was most pronounced within 90 days post-immunization, particularly for RM cases.

Keywords:
immunizationimplantation failurelive birth ratepaternal lymphocytesrecurrent miscarriage

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Area of Science:

  • Reproductive Immunology
  • Obstetrics & Gynecology

Background:

  • Recurrent implantation failure (RIF) and recurrent miscarriage (RM) affect many couples, with idiopathic causes in ~50%.
  • Immunological factors are a key research focus for RIF and RM.
  • Paternal lymphocyte immunotherapy (LIT) is being investigated as a potential treatment.

Purpose of the Study:

  • To evaluate live birth rates in couples undergoing lymphocyte immunotherapy (LIT) with paternal lymphocytes.
  • To assess the efficacy of LIT for women with a history of recurrent miscarriage (RM) and/or recurrent implantation failure (RIF).

Main Methods:

  • Retrospective study of 148 couples with RM and/or RIF.
  • Women received immunization with lymphocytes from their male partner (LIT).
  • Data collected from November 2017 to August 2019.

Main Results:

  • Overall live birth rate was 43% (55 out of 148 patients).
  • Significantly higher live birth rates were observed in the RM (53%) and combined RM/RIF (59%) groups compared to the RIF-only group (33%, p=0.02).
  • The conception rate leading to live births within 90 days was significantly higher for RM and combined groups (31%, 23%) versus RIF (8%, p=0.005).

Conclusions:

  • Lymphocyte immunotherapy (LIT) demonstrated high live birth rates, particularly in women with recurrent miscarriage.
  • While not recommended for routine therapy due to limited randomized data, LIT may be considered for individual cases of RIF/RM.
  • Early conception following LIT appears crucial for its success in improving live birth rates.