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Cisplatin Mouse Models: Treatment, Toxicity and Translatability
1Medical Experimental Centre, Institute of Pathology, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.
Biomedicines
|October 23, 2021
Summary
Cisplatin chemotherapy causes significant side effects in both humans and mice. Improving mouse models by optimizing protocols and supportive care is crucial for developing better cancer treatments.
Area of Science:
- Oncology
- Pharmacology
- Toxicology
Background:
- Cisplatin is a cornerstone chemotherapy agent for various cancers.
- Significant toxicities limit cisplatin efficacy and patient outcomes.
- Current mouse models for cisplatin research have critical protocol limitations.
Purpose of the Study:
- To review and critique existing cisplatin mouse models.
- To highlight the complexity of cisplatin-induced toxicities.
- To propose improvements for preclinical cisplatin research.
Main Methods:
- Literature review of characterized cisplatin protocols in mice.
- Analysis of cisplatin's dose- and time-dependent effects.
- Comparison of murine and human responses to cisplatin.
Main Results:
- Mice exhibit similar cisplatin toxicities (nephrotoxicity, gastrointestinal, neuro-, oto-, myelotoxicity) as humans.
- Interconnected pathomechanisms underlie multi-organ toxicity.
- Current protocols often neglect crucial supportive care and hydration.
Conclusions:
- Optimizing mouse models is essential for advancing cisplatin research.
- Treating animal models as patients, not tools, will improve clinical translation.
- Enhanced understanding of toxicity mechanisms can guide therapeutic development.
