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BAZ1B the Protean Protein.

Shahin Behrouz Sharif1, Nina Zamani2, Brian P Chadwick1

  • 1Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.

Genes
|October 23, 2021
PubMed
Summary
This summary is machine-generated.

Bromodomain adjacent to the zinc finger domain 1B (BAZ1B) is a versatile protein involved in DNA repair and chromatin remodeling. Its hemizygosity contributes to Williams syndrome phenotypes and has implications in cancer.

Keywords:
B-WICHBAZ1ABAZ: WICHISWIWSTFchromatin remodelinghSNF2H

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Area of Science:

  • Genetics
  • Molecular Biology
  • Developmental Biology

Background:

  • Williams syndrome (WS) is a genetic disorder caused by a deletion on chromosome 7q11.23.
  • The bromodomain adjacent to the zinc finger domain 1B (BAZ1B) gene is located within this deleted region.
  • BAZ1B hemizygosity is implicated in several WS phenotypes.

Purpose of the Study:

  • To provide a comprehensive review of BAZ1B functions.
  • To summarize the known roles of BAZ1B in cellular processes.
  • To highlight the emerging link between BAZ1B and cancer.

Main Methods:

  • Literature review of studies on BAZ1B.
  • Analysis of patient data with atypical deletions.
  • Examination of mouse models for WS phenotypes.

Main Results:

  • BAZ1B is a versatile nuclear protein involved in chromatin remodeling, DNA replication and repair, and transcription.
  • BAZ1B participates in processes involving RNA Polymerases I, II, and III.
  • BAZ1B exhibits kinase activity.

Conclusions:

  • BAZ1B plays a crucial role in multiple fundamental cellular processes.
  • BAZ1B hemizygosity contributes to the complex phenotype of Williams syndrome.
  • BAZ1B is a potential factor in cancer development.