Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

4.3K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.3K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

5.6K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.6K
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

1.8K
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring glucocorticoid receptor signalling in lymphangioleiomyomatosis.

ERJ open research·2026
Same author

Retraction: Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion.

The Journal of experimental medicine·2026
Same author

Genomic analysis of BCG unresponsive non-muscle-invasive bladder cancer identifies drivers of sensitivity to intravesical Gemcitabine/Docetaxel.

bioRxiv : the preprint server for biology·2026
Same author

Clinicopathologic characterization of renal tumors with Folliculin (FLCN) biallelic inactivation.

Virchows Archiv : an international journal of pathology·2026
Same author

Ninth BHD International Symposium: Advancing research through global collaboration.

Cell stress & chaperones·2026
Same author

Cribriform/Intraductal carcinoma exhibits superior prognostic value over Gleason pattern 4 percentage and tertiary pattern 5 in Gleason pattern 4 prostate cancer.

World journal of urology·2026

Related Experiment Video

Updated: Oct 16, 2025

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
11:27

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy

Published on: April 29, 2014

16.9K

Renal Cell Carcinoma in Tuberous Sclerosis Complex.

Elizabeth P Henske1, Kristine M Cornejo2, Chin-Lee Wu2

  • 1Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Genes
|October 23, 2021
PubMed
Summary

Tuberous sclerosis complex (TSC) is a genetic disorder with prominent kidney problems. Recent research clarifies TSC-associated kidney cancer, revealing distinct features and molecular links to other kidney tumor types.

Keywords:
RCC with leiomyomatous stromaTSC1TSC2chromophobe RCCeosinophilic solid cystic RCChybrid oncocytic chromophobe tumorrenal cell carcinomatuberous sclerosis complex

More Related Videos

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

13.8K
Microfluidic Co-culture of Renal Healthy and Tumor Epithelium to Model Kidney Cancer Progression
06:29

Microfluidic Co-culture of Renal Healthy and Tumor Epithelium to Model Kidney Cancer Progression

Published on: January 31, 2025

865

Related Experiment Videos

Last Updated: Oct 16, 2025

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
11:27

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy

Published on: April 29, 2014

16.9K
A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

13.8K
Microfluidic Co-culture of Renal Healthy and Tumor Epithelium to Model Kidney Cancer Progression
06:29

Microfluidic Co-culture of Renal Healthy and Tumor Epithelium to Model Kidney Cancer Progression

Published on: January 31, 2025

865

Area of Science:

  • Nephrology
  • Oncology
  • Genetics

Background:

  • Tuberous sclerosis complex (TSC) is an autosomal dominant disorder.
  • Renal manifestations, including angiomyolipomas, cysts, and renal cell carcinoma (RCC), are prominent in TSC.
  • Recent advances have significantly improved the understanding of TSC-associated RCC.

Purpose of the Study:

  • To summarize recent advances in understanding TSC-associated RCC.
  • To detail the pathologic features and molecular underpinnings of TSC-associated RCC.
  • To explore links between TSC-associated tumors and other renal neoplasms.

Main Methods:

  • Review of recent clinical series and molecular studies on TSC-associated RCC.
  • Analysis of pathologic features of TSC-associated RCC.
  • Investigation of somatic mutations in TSC1/TSC2/mTOR pathways.
  • Exploration of molecular links involving TFEB/TFE3 transcription factors.

Main Results:

  • TSC-associated RCC shows a mean age of onset of 36 years, with cases in children as young as 7.
  • A striking 2:1 female predominance is observed in TSC-RCC.
  • Pathologic features include chromophobe-like aspects, eosinophilia, and unclassified tumors, with similarities to Birt-Hogg-Dube-associated RCC.
  • Sporadic tumors with somatic TSC1/TSC2/mTOR mutations share morphologic and immunophenotypic features with germline TSC-related tumors.
  • Molecular links between TSC and BHD-associated tumors involve TFEB/TFE3 transcription factors.

Conclusions:

  • TSC-associated RCC is a distinct entity with characteristic clinical and pathologic features.
  • Somatic mutations in TSC1/TSC2/mTOR pathways contribute to a spectrum of renal neoplasms.
  • Shared molecular pathways, such as TFEB/TFE3, link different hereditary and sporadic kidney cancer types.