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Heart Failure in Patients with Arrhythmogenic Cardiomyopathy

Shi Chen1, Liang Chen1, Firat Duru2,3

  • 1Department of Cardiac Surgery, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167A Beilishi Road, Xi Cheng District, Beijing 100037, China.

Journal of Clinical Medicine
|October 23, 2021
PubMed

Insights

Arrhythmogenic cardiomyopathy (ACM) can lead to heart failure (HF), a serious complication. This review covers recent advancements in understanding and managing HF in ACM patients, including updated clinical guidelines.

Area of Science:

  • Cardiology
  • Genetics
  • Heart Failure Research

Background:

  • Arrhythmogenic cardiomyopathy (ACM) is an inherited heart muscle disease characterized by fibro-fatty replacement.
  • ACM is a significant cause of sudden cardiac death, particularly in young athletes.
  • Heart failure (HF) development is an increasingly recognized complication of ACM progression.

Purpose of the Study:

  • To provide a comprehensive review of the current understanding of heart failure (HF) in arrhythmogenic cardiomyopathy (ACM).
  • To summarize research progress on the epidemiology, clinical characteristics, risk stratification, and therapeutics of HF in ACM.
  • To highlight recent updates in clinical management guidelines for HF in ACM.

Main Methods:

  • Literature review of recent research on HF in ACM.
  • Analysis of epidemiological data and clinical characteristics.
  • Evaluation of current risk stratification tools and therapeutic strategies.

Main Results:

  • ACM is associated with significant HF development, impacting patient prognosis.
  • Updated guidelines offer improved strategies for HF management in ACM.
  • Risk stratification and therapeutic approaches are evolving.

Conclusions:

  • Heart failure is a critical aspect of ACM that requires dedicated management.
  • Recent advancements have improved the care and outcomes for ACM patients with HF.
  • Continued research is essential for further refining HF management in ACM.

Keywords:
arrhythmogenic ventricular cardiomyopathyheart failureprognosisrisk stratification

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