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[Behavior of glucosephosphate isomerase in children with malignant diseases]

P Hohenberger, N Graf, F C Sitzmann

    Monatsschrift Kinderheilkunde : Organ Der Deutschen Gesellschaft Fur Kinderheilkunde
    |November 1, 1986
    PubMed

    Insights

    Glucose-phosphate-isomerase (GPI) levels vary in children and are elevated in various conditions, not just tumors. Elevated GPI in osteogenic sarcoma or medulloblastoma correlates with tumor stage, but it is not a reliable tumor marker for all cancers.

    Area of Science:

    • Biochemistry and Clinical Enzymology
    • Pediatric Oncology Biomarkers

    Context:

    • Glucose-phosphate-isomerase (GPI) is an enzyme found in plasma.
    • Normal GPI ranges differ significantly across pediatric age groups.
    • Elevated GPI has been observed in various pediatric conditions.

    Purpose:

    • To evaluate the diagnostic utility of plasma glucose-phosphate-isomerase (GPI) activity as a tumor marker in children.
    • To correlate GPI activity with clinical tumor stage in specific pediatric malignancies.
    • To assess the reliability of GPI as a general tumor marker across different pediatric cancers and non-malignant conditions.

    Summary:

    • Plasma GPI levels exhibit age-dependent variations in children, with established normal ranges.
    • While GPI activity correlates with tumor stage in osteogenic sarcoma and medulloblastoma, its sensitivity is low in Ewing sarcoma and myeloid leukemia.
    • High GPI activity is also observed in non-malignant conditions like cystic fibrosis, diabetes mellitus, and muscular dystrophy, limiting its specificity.

    Impact:

    • Plasma GPI is not a universally valid tumor marker for pediatric cancers due to inconsistent correlation and elevation in non-malignant diseases.
    • Routine measurement of GPI activity is not recommended as part of standard enzyme chemistry in pediatric diagnostics.
    • This study clarifies the limited role of GPI in pediatric oncology, guiding diagnostic strategies and resource allocation.

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