Related Experiment Video
Updated: Oct 15, 2025
06:31
Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis
Published on: October 6, 2023
2.5K
Identifying Clinicoradiological Phenotypes in Diffuse Idiopathic Skeletal Hyperostosis: A Cross-Sectional Study
Teresa Clavaguera1, Patrícia Reyner1, Maria Buxó2
1Servei de Reumatologia, Hospitals Universitari Josep Trueta i Hospital, Santa Caterina, 17007 Salt, Spain.
Medicina (Kaunas, Lithuania)
|October 23, 2021
Summary
Diffuse idiopathic skeletal hyperostosis (DISH) presents distinct phenotypes. A peripheral pattern (PP) of DISH, characterized by enthesopathies, is identified and warrants inclusion in future classification criteria.
Area of Science:
- Rheumatology
- Orthopedics
- Radiology
Background:
- Diffuse idiopathic skeletal hyperostosis (DISH) is a bone overgrowth disorder.
- Current classification criteria for DISH primarily focus on skeletal signs.
Purpose of the Study:
- To describe distinct phenotypes of DISH based on clinicoradiological features.
- To identify potential new classification criteria for DISH.
Main Methods:
- Evaluated 97 patients diagnosed with DISH between 2004 and 2015.
- Stratified patients into peripheral pattern (PP), axial pattern (AP), and mixed pattern (MP) based on enthesopathy and Resnick criteria.
- Performed statistical analysis to identify predictive variables for each DISH pattern.
Main Results:
- 57.7% of patients were male; 72.2% met Resnick criteria.
- 39.7% were classified as MP, 30.9% as AP, and 29.4% as PP.
- Peripheral pattern (PP) showed a predominance of women, earlier onset, hip involvement, and enthesitis. Axial pattern (AP) had more asymptomatic patients, while mixed pattern (MP) indicated more extensive disease.
Conclusions:
- DISH exhibits distinct phenotypes, including a previously underrecognized peripheral pattern (PP).
- Extravertebral manifestations should be incorporated into new DISH classification criteria to encompass the full disease spectrum.
