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An Observational Real-Life Study with a New Infant Formula in Infants with Functional Gastro-Intestinal Disorders

Yvan Vandenplas1, Laetitia Gerlier2, Karin Caekelbergh2

  • 1KidZ Health Castle, Vrije Universiteit Brussel (VUB), UZ Brussel, 1090 Brussels, Belgium.

Nutrients
|October 23, 2021
PubMed

Insights

A specialized infant formula significantly reduced functional gastro-intestinal disorders (FGIDs) and improved quality of life within days. This nutritional intervention offers effective relief for infants experiencing FGIDs.

Area of Science:

  • Pediatrics
  • Gastroenterology
  • Nutritional Science

Background:

  • Functional gastro-intestinal disorders (FGIDs) significantly impact infant and family well-being.
  • Existing management strategies for FGIDs in infants often require improvement.

Purpose of the Study:

  • To evaluate the efficacy of a specialized infant formula in managing FGIDs.
  • To assess the impact of the formula on infant quality of life.

Main Methods:

  • A two-week intervention with a formula containing partial whey hydrolysate, starch, magnesium, prebiotics (FOS/GOS), and probiotic *Lactobacillus reuteri* DSM 17938.
  • 196 infants with at least two FGIDs were enrolled.
  • Efficacy measured by Cow Milk-associated Symptom Score (CoMiSS) and quality of life by QUALIN score.

Main Results:

  • Significant reduction in FGIDs within three days (CoMiSS decrease: -1.29, p < 0.0001).
  • Improved infant quality of life observed after seven days (QUALIN increase: +1.4, p = 0.008).
  • Constipation incidence decreased from 18.8% to 6.5% within three days.

Conclusions:

  • The specialized infant formula effectively alleviates FGIDs and enhances quality of life.
  • This nutritional approach, combined with guidance, proves beneficial in real-world infant care settings.
  • Early intervention with targeted nutrition can positively influence infant gastro-intestinal health.

Keywords:
CoMiSSQUALINcolicconstipationcryingfunctional gastro-intestinal disordergastro-esophageal refluxquality of liferegurgitation

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