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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

466
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
466
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

859
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
859
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

977
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
977
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

532
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
532
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

16
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
16
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

15
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
15

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Updated: May 1, 2026

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
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PLGA Core-Shell Nano/Microparticle Delivery System for Biomedical Application.

Se Min Kim1, Madhumita Patel2, Rajkumar Patel3

  • 1Life Science and Biotechnology Department (LSBT), Underwood Division (UD), Underwood International College, Yonsei University, Sinchon, Seoul 03722, Korea.

Polymers
|October 23, 2021
PubMed
Summary
This summary is machine-generated.

Poly (lactic-co-glycolic acid) (PLGA) core-shell nanoparticles offer advanced drug delivery for cancer therapy and tissue regeneration. These particles protect drugs and enable controlled release, showing significant biomedical potential.

Keywords:
anti-cancer activitycore–shell particledrug deliveryperiodontal regenerationtissue engineering

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Core-shell particles possess unique structures enabling diverse biomedical applications at nano/micro scales.
  • Poly (lactic-co-glycolic acid) (PLGA), an FDA-approved polymer, is a recognized material for drug delivery vehicles.
  • These particles are crucial for sequence-controlled drug release and offer drug protection.

Purpose of the Study:

  • To review poly (lactic-co-glycolic acid) (PLGA) core-shell nano/microparticles.
  • To summarize drug delivery systems utilizing these particles for cancer therapy.
  • To explore applications in tissue regeneration, including bone, cartilage, and periodontal regeneration.

Main Methods:

  • Literature review of PLGA core-shell nano/microparticle applications.
  • Analysis of drug delivery mechanisms for cancer treatment.
  • Evaluation of regenerative medicine strategies using PLGA particles.

Main Results:

  • PLGA core-shell particles demonstrate significant potential in controlled drug delivery.
  • These systems are effective for targeted cancer therapy.
  • Promising outcomes observed in bone, cartilage, and periodontal tissue regeneration.

Conclusions:

  • PLGA core-shell nano/microparticles are versatile platforms for advanced biomedical applications.
  • Their unique structure facilitates effective drug delivery for cancer and regeneration.
  • Further research into PLGA-based systems will advance therapeutic strategies.