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Medical Management of Peripheral Artery Disease

Tara A Holder1, J Antonio Gutierrez2, Aaron W Aday3

  • 1Division of Cardiovascular Medicine, Vanderbilt University Medical Center, 2220 Pierce Avenue, 383 PRB, Nashville, TN 37232-0021, USA. Electronic address: https://twitter.com/TaraHolder17.

Cardiology Clinics
|October 23, 2021
PubMed

Insights

Peripheral artery disease (PAD) management includes lifestyle changes and medications. New antiplatelet and antithrombotic treatments further reduce cardiovascular and limb event risks in PAD patients.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Pharmacology

Background:

  • Peripheral artery disease (PAD) is a common yet undertreated atherosclerotic condition.
  • PAD significantly increases morbidity and mortality.
  • Optimal medical therapy is crucial for managing PAD patients.

Purpose of the Study:

  • To review the essential components of optimal medical therapy for peripheral artery disease.
  • To discuss the evidence supporting current and novel therapeutic strategies for PAD.
  • To highlight advancements in antiplatelet and antithrombotic treatments for PAD.

Main Methods:

  • This review synthesizes data from recent clinical trials and guidelines.
  • It focuses on established and emerging pharmacological interventions.
  • Evidence for smoking cessation, lipid-lowering, and hypertension treatment is examined.

Main Results:

  • Standard therapies include smoking cessation, lipid-lowering, and hypertension control.
  • Novel antiplatelet and antithrombotic agents have shown significant benefits.
  • These newer therapies reduce the risk of major adverse cardiovascular and limb events.

Conclusions:

  • Optimal medical therapy for PAD is multifaceted, combining lifestyle modifications and pharmacotherapy.
  • Emerging antiplatelet and antithrombotic therapies represent significant advancements in PAD management.
  • Aggressive management of risk factors and utilization of novel therapies are key to improving outcomes in PAD.

Keywords:
Antiplatelet therapyAntithrombotic therapyPeripheral artery diseaseSmoking cessationStatins

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