Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Immunological Memory

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...

Cells of the Adaptive Immune Response

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

Inflammatory Response

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...

Immune Response Against Viral Pathogens

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Circadian screening of neutrophils identifies therapeutic targets in multiple sclerosis.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

Age at menarche association with metabolic, reproductive, and sociodemographic factors: a population-based cross-sectional analysis using an outcome-wide framework in Geneva, Switzerland.

European journal of public health·2026

Same author

Who declines genetic counseling? An assessment of genetic counseling declination among individuals participating in a population-wide genomic screening program.

Patient education and counseling·2026

Same author

Precision medicine's inevitable trajectory toward rare-disease-sized cohorts: implications for machine learning and deep learning.

The Lancet. Digital health·2026

Same author

Hetairos is a histology-based artificial intelligence model for predicting central nervous system tumor methylation subtypes.

Nature cancer·2026

Same author

What it Takes to Implement Population-Based Genomic Screening: A Multi-Site Qualitative Study of Implementation Determinants Across Health Systems.

Research square·2026

Search research articles

Related Experiment Video

Updated: Oct 15, 2025

Strategies for Study of Neuroprotection from Cold-preconditioning

Strategies for Study of Neuroprotection from Cold-preconditioning

Published on: September 2, 2010

Cold exposure protects from neuroinflammation through immunologic reprogramming.

Martina Spiljar¹, Karin Steinbach², Dorothée Rigo¹

¹Department of Cell Physiology and Metabolism, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland; Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Cell Metabolism

|October 23, 2021

Summary

This summary is machine-generated.

Cold exposure ameliorates experimental autoimmune encephalomyelitis (EAE) by modulating monocytes, reducing T-cell priming. This suggests an energetic trade-off between cold adaptation and autoimmunity, benefiting immune-mediated diseases.

Keywords:

T cell priming autoimmunity bone marrow cold exposure experimental autoimmune encephalomyelitis immunometabolism inflammation monocytes multiple sclerosis neuroinflammation

More Related Videos

Characterization and Isolation of Mouse Primary Microglia by Density Gradient Centrifugation

Characterization and Isolation of Mouse Primary Microglia by Density Gradient Centrifugation

Published on: February 16, 2018

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

Related Experiment Videos

Last Updated: Oct 15, 2025

Strategies for Study of Neuroprotection from Cold-preconditioning

Strategies for Study of Neuroprotection from Cold-preconditioning

Published on: September 2, 2010

Characterization and Isolation of Mouse Primary Microglia by Density Gradient Centrifugation

Characterization and Isolation of Mouse Primary Microglia by Density Gradient Centrifugation

Published on: February 16, 2018

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

Area of Science:

Immunology
Neuroscience
Metabolic studies

Background:

Autoimmunity imposes significant metabolic costs.
The role of Ly6C-high monocytes in priming T cells in CNS autoimmunity is not fully understood.

Purpose of the Study:

To investigate the impact of cold exposure on immunity and immune-mediated diseases.
To elucidate the role of monocytes in cold-induced immune modulation during experimental autoimmune encephalomyelitis (EAE).

Main Methods:

Unbiased analysis of immune changes in various compartments during cold exposure in mouse models.
Assessment of monocyte MHCII expression, T-cell priming, and pathogenicity.
Monocyte depletion and adoptive transfer of T helper cells.

Main Results:

Cold exposure significantly ameliorates active EAE.
Cold exposure decreases monocyte MHCII expression and suppresses T-cell priming and pathogenicity.
Monocyte modulation is critical for the cold-induced protective effects.

Conclusions:

Environmental temperature influences neuroinflammation through monocyte modulation.
Cold-induced metabolic adaptations may compete with autoimmunity, offering a therapeutic benefit for immune-mediated diseases.