Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Two-Dimensional (2D) NMR: Overview01:12

Two-Dimensional (2D) NMR: Overview

975
The 1D NMR spectrum of large and complex molecules like natural products has complicated splitting patterns and overlapping signals, which can be easily interpreted using 2-dimensional (2D) NMR. Unlike 1D NMR, 2D NMR has two frequency axes that provide the coupling information between the nucleus A and nucleus B in a molecule. The process from which 2D spectra are obtained has four steps.
The first step is the preparation period, during which nucleus A is excited with a radiofrequency pulse....
975
Atomic Nuclei: Magnetic Resonance01:05

Atomic Nuclei: Magnetic Resonance

815
The number of nuclear spins aligned in the lower energy state is slightly greater than those in the higher energy state. In the presence of an external magnetic field, as the spins precess at the Larmor frequency, the excess population results in a net magnetization oriented along the z axis. When a pulse or a short burst of radio waves at the Larmor frequency is applied along the x axis, the coupling of frequencies causes resonance and flips the nuclear spins of the excess population from the...
815
2D NMR: Overview of Homonuclear Correlation Techniques01:16

2D NMR: Overview of Homonuclear Correlation Techniques

332
Homonuclear correlation spectroscopy (COSY) is a powerful technique used in Nuclear Magnetic Resonance (NMR) spectroscopy to study the correlations between nuclei of the same type within a molecule. It provides information about scalar couplings between adjacent nuclei, which helps determine connectivity and structural information. There are several COSY variants, each with its unique strengths and experimental parameters.
COSY90 is the standard two-dimensional (2D) COSY experiment that...
332
¹H NMR: Interpreting Distorted and Overlapping Signals01:02

¹H NMR: Interpreting Distorted and Overlapping Signals

1.2K
Spin systems where the difference in chemical shifts of the coupled nuclei is greater than ten times J are called first-order spin systems. These nuclei are weakly coupled, and their chemical shifts and coupling constant can generally be estimated from the well-separated signals in the spectrum.
As Δν decreases and the signals move closer, the doublets appear increasingly distorted. The intensities of the inner lines increase at the cost of those of the outer lines as the signals are...
1.2K
Double Resonance Techniques: Overview01:12

Double Resonance Techniques: Overview

355
Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...
355
π Electron Effects on Chemical Shift: Aromatic and Antiaromatic Compounds01:14

π Electron Effects on Chemical Shift: Aromatic and Antiaromatic Compounds

1.4K
In aromatic compounds, such as benzene, the circulation of (4n + 2) π-electrons sets up a diamagnetic or diatropic ring current around the perimeter of the molecule. This current induces a magnetic field that opposes the external field inside the ring and reinforces it on the outside. The protons in benzene are deshielded and exhibit high chemical shifts in the range 6.5–8.5 ppm. The shielding effect at the center of the ring is evident in complex aromatic molecules, such as...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Contact Angle Mapping Using Microdroplets.

Langmuir : the ACS journal of surfaces and colloids·2025
Same author

Adsorption of Polar Species at Crude Oil-Water Interfaces: the Chemoelastic Behavior.

Langmuir : the ACS journal of surfaces and colloids·2022
Same author

Mapping the human connectome using diffusion MRI at 300 mT/m gradient strength: Methodological advances and scientific impact.

NeuroImage·2022
Same author

Analytical models of probe dynamics effects on NMR measurements.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2021
Same author

Multiphysics NMR correlation spectroscopy.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2020
Same author

Optimization of multidimensional MR data acquisition for relaxation and diffusion.

NMR in biomedicine·2020
Same journal

Localization-driven exchange contrast in diffusion exchange spectroscopy.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2026
Same journal

4.5 Tesla superconducting miniature magnet in liquid nitrogen.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2026
Same journal

Folding and unfolding dynamics of a DNA aptamer studied by heteronuclear <sup>1</sup>H-<sup>13</sup>C correlation zz-exchange spectroscopy.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2026
Same journal

Multi-spin control from one-spin pulses.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2026
Same journal

Altering MRI rotating frame relaxations by changing the truncation level of Hyperbolic Secant pulse.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2026
Same journal

Effects of proton exchange on the lifetimes of long-lived states in aliphatic chains.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2026
See all related articles

Related Experiment Video

Updated: Oct 15, 2025

High-Temperature and High-Pressure In situ Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy
08:55

High-Temperature and High-Pressure In situ Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy

Published on: October 9, 2020

5.7K

Inside-out NMR with two concentric ring magnets.

Shin Utsuzawa1, Yiqiao Tang1, Yi-Qiao Song2

  • 1Schlumberger-Doll Research, Cambridge, MA 02139, USA.

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|October 23, 2021
PubMed
Summary
This summary is machine-generated.

This study introduces a compact, inside-out Nuclear Magnetic Resonance (NMR) sensor. The novel design offers a large, uniform magnetic field for sensitive measurements, ideal for various applications.

Keywords:
Barrel magnetInhomogeneous fieldsInside-out NMRLow-cost NMRMobile NMRSaddle pointSingle-sided NMRUnilateral NMR

More Related Videos

Measuring Interactions of Globular and Filamentous Proteins by Nuclear Magnetic Resonance Spectroscopy NMR and Microscale Thermophoresis MST
10:28

Measuring Interactions of Globular and Filamentous Proteins by Nuclear Magnetic Resonance Spectroscopy NMR and Microscale Thermophoresis MST

Published on: November 2, 2018

12.3K
Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex
10:52

Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex

Published on: July 27, 2022

3.0K

Related Experiment Videos

Last Updated: Oct 15, 2025

High-Temperature and High-Pressure In situ Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy
08:55

High-Temperature and High-Pressure In situ Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy

Published on: October 9, 2020

5.7K
Measuring Interactions of Globular and Filamentous Proteins by Nuclear Magnetic Resonance Spectroscopy NMR and Microscale Thermophoresis MST
10:28

Measuring Interactions of Globular and Filamentous Proteins by Nuclear Magnetic Resonance Spectroscopy NMR and Microscale Thermophoresis MST

Published on: November 2, 2018

12.3K
Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex
10:52

Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex

Published on: July 27, 2022

3.0K

Area of Science:

  • Magnetic Resonance Imaging
  • Sensor Technology
  • Spectroscopy

Background:

  • Traditional NMR sensors often have limited sensitive regions and require complex setups.
  • Developing portable and cost-effective NMR solutions remains a challenge for broader applications.

Purpose of the Study:

  • To design and implement a novel inside-out Nuclear Magnetic Resonance (NMR) sensor.
  • To achieve a large sensitive region with a uniform magnetic field at a remote location.
  • To demonstrate the sensor's capability for measuring samples with long relaxation times and high diffusivity.

Main Methods:

  • Utilized a simple construction with a pair of ring magnets for the inside-out NMR sensor.
  • Optimized the sensor geometry to create a 'sweet spot' with quasi-uniform B0 field.
  • Integrated a coil printed circuit board (PCB) and housing for a palm-size device.

Main Results:

  • Achieved a large sensitive region (approx. 4 mm width x 5 mm height) with a uniform magnetic field (0.16 T) at 5 mm above the magnet surface.
  • Demonstrated high signal-to-noise ratio (SNR ~23 per two scans) with low radiofrequency (RF) power (~10 W peak).
  • Successfully measured samples with T2 = 1.5 s and a 100 μs echo time, indicating suitability for long T2 and high diffusivity samples.

Conclusions:

  • The developed inside-out NMR sensor offers a cost-effective and portable solution.
  • Its design enables measurements in large sample volumes with enhanced sensitivity.
  • The sensor shows promise for applications requiring precise NMR measurements of challenging samples.