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Updated: Nov 8, 2025

Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments
Published on: November 1, 2024
Analytical models of probe dynamics effects on NMR measurements
Mason Greer1, David Ariando2, Martin Hurlimann3
1Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA.
Abstract:
This paper provides a detailed analysis of three common NMR probe circuits (untuned, tuned, and impedance-matched) and studies their effects on multi-pulse experiments, such as those based on the Carr-Purcell-Meiboom-Gill (CPMG) pulse sequence. The magnitude of probe dynamics effects on broadband refocusing pulses are studied as a function of normalized RF bandwidth. Finally, the probe circuit models are integrated with spin dynamics simulations to design hardware-specific RF excitation and refocusing pulses for optimizing user-specified metrics such as signal-to-noise ratio (SNR) in grossly inhomogeneous fields. Preliminary experimental results on untuned probes are also presented.
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