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The A118G single-nucleotide polymorphism in OPRM1 is a risk factor for asthma severity

Kaori Kawakami1, Tomomitsu Miyasaka1, Yutaka Nakamura2

  • 1Division of Pathophysiology, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, Japan.

Allergology International : Official Journal of the Japanese Society of Allergology
|October 24, 2021
PubMed
Summary

The OPRM1 GG genotype is linked to increased asthma severity and airway hyperresponsiveness. This genetic variation enhances allergic immune responses, particularly Th2 cell differentiation, in asthma patients.

Keywords:
A118GAllergic asthmaOPRM1PolymorphismTh2 cell differentiation

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