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(Im)precise trial descriptions.

Daniel I Sessler1

  • 1Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, USA.

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|October 25, 2021
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Summary
This summary is machine-generated.

Redundant terms like "prospective" and "controlled" can distract from the core meaning of randomised trials. Reserve "pragmatic" for trials with minimal controls and "pilot" for those specifically designed and registered as such.

Keywords:
controlled trialpilot studypragmatic studyreal-world studytitle

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Area of Science:

  • Clinical Trial Design
  • Research Methodology
  • Scientific Terminology

Background:

  • Redundant terminology in clinical trial reporting can obscure trial characteristics and intent.
  • Terms like 'prospective', 'interventional', and 'controlled' are often superfluous in the context of randomised trials.

Discussion:

  • The term 'pragmatic' should be reserved for trials intentionally controlling little beyond the exposure.
  • 'Pilot' trials should be specifically designated, registered, and possess appropriate pilot outcomes.
  • Misuse of 'pragmatic', 'real-world', or 'pilot' can mask poor trial design or inadequate statistical power.

Key Insights:

  • Standardized and precise language is crucial for accurate interpretation of clinical trial results.
  • Clear definitions for trial descriptors like 'pragmatic' and 'pilot' enhance scientific communication.
  • Avoiding redundant or misused terms improves the clarity and integrity of research reporting.

Outlook:

  • Promoting consistent and accurate terminology in clinical trial reporting will improve scientific discourse.
  • Future research should focus on establishing clear guidelines for trial descriptors.
  • Enhanced clarity in trial design reporting will facilitate better evidence synthesis and application.