Increased 68Ga-FAPI Uptake in Sacral Chordoma.

Area of Science:

• Oncology
• Radiology
• Nuclear Medicine

Background:

• Chordomas are rare malignant bone tumors arising from notochordal remnants.
• Sacral chordomas can present with vague symptoms like low back pain, delaying diagnosis.

Observation:

• A 47-year-old woman presented with persistent low back pain.
• CT imaging revealed a soft tissue mass in the S3-S4 vertebral bodies.
• The patient participated in a clinical trial using 68Ga-FAPI PET imaging.

Findings:

• Significant 68Ga-FAPI tracer uptake was observed in the sacral region.
• Postoperative pathology confirmed the diagnosis of sacral chordoma.

Implications:

• 68Ga-FAPI PET imaging shows promise for the diagnosis of sacral chordoma.
• This case highlights the utility of novel radiotracers in identifying rare tumors.