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Indomethacin-Induced Hypertensive Crisis
Bibek Dhungana1, Sajog Kansakar2, Palak Paudel3
1Internal Medicine, KIST Medical College, Lalitpur, NPL.
Cureus
|October 25, 2021
Summary
Non-steroidal anti-inflammatory drugs (NSAIDs) can increase blood pressure. A single dose of indomethacin, a potent NSAID, caused a hypertensive crisis in one patient, highlighting potential cardiovascular risks.
Area of Science:
- Pharmacology
- Cardiovascular Medicine
- Clinical Case Studies
Background:
- Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for pain relief and inflammation.
- NSAID use is linked to adverse effects, including hypertension.
- Different NSAIDs exhibit varying impacts on blood pressure.
Observation:
- A case study involving a 58-year-old woman is presented.
- The patient experienced a hypertensive crisis following a single dose of prescription indomethacin.
- Indomethacin is noted for its potential to significantly elevate blood pressure.
Findings:
- NSAIDs, particularly indomethacin, can precipitate severe blood pressure increases.
- A single dose of indomethacin was sufficient to trigger a hypertensive crisis in a susceptible individual.
- This case underscores the critical relationship between NSAID administration and blood pressure regulation.
Implications:
- Clinicians should exercise caution when prescribing indomethacin, especially in patients with pre-existing hypertension or cardiovascular risk factors.
- Awareness of NSAID-induced hypertension is crucial for patient safety and effective pain management.
- Further research into NSAID-specific cardiovascular risks is warranted to guide clinical practice.
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