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Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Pericarditis I: Introduction01:22

Pericarditis I: Introduction

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Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
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The JAK-STAT Signaling Pathway01:20

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Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

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Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
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Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Updated: Oct 15, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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Reactive Arthritis Post-SARS-CoV-2.

Faizal Ouedraogo1, Rachita Navara2, Rusha Thapa3

  • 1Department of Medicine, University of Maryland Capital Region Health, Largo, USA.

Cureus
|October 25, 2021
PubMed
Summary
This summary is machine-generated.

Reactive arthritis (ReA) can occur after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This case report highlights ReA as a potential complication in COVID-19 survivors presenting with joint pain.

Keywords:
case reportcovid-19polyarthritisreactive arthritissars-cov-2

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Area of Science:

  • Rheumatology
  • Infectious Diseases
  • Immunology

Background:

  • Reactive arthritis (ReA) is typically associated with bacterial infections of the genitourinary and gastrointestinal tracts.
  • Post-viral reactive arthritis is less common, with limited documented cases following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

Observation:

  • A 45-year-old male developed polyarthritis (shoulders, elbow, knee) three weeks after hospitalization for severe COVID-19.
  • Readmission revealed inflammatory arthritis with elevated markers and aseptic synovial fluid, negative for common infectious and autoimmune causes.
  • The patient's symptoms were consistent with ReA, following a severe SARS-CoV-2 infection complicated by multiorgan failure.

Findings:

  • The patient experienced recurrent symptoms responsive to corticosteroid treatment, indicating an inflammatory arthritic process.
  • Extensive workup excluded common infectious pathogens and autoimmune markers associated with other forms of arthritis.
  • The clinical presentation and laboratory findings strongly suggested ReA secondary to SARS-CoV-2 infection.

Implications:

  • This case adds to the limited literature on ReA post-SARS-CoV-2 infection, suggesting a need to consider this diagnosis in COVID-19 survivors with polyarthritis.
  • Early recognition and treatment with corticosteroids may improve outcomes for patients with post-COVID-19 reactive arthritis.
  • Understanding SARS-CoV-2 pathophysiology may reveal mechanisms driving post-infectious autoimmune sequelae like ReA.