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Overview of Exosomes

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...

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Related Experiment Video

Updated: Oct 15, 2025

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Published on: December 5, 2018

Exosomes, a New Star for Targeted Delivery.

Huizhi Chen¹, Liyan Wang¹, Xinling Zeng^1,2

¹School of Pharmacy, Guangdong Medical University, Dongguan, China.

Frontiers in Cell and Developmental Biology

|October 25, 2021

Summary

Engineered exosomes show potential for targeted drug delivery. Researchers are developing advanced exosome-based systems to improve selectivity and effectiveness for clinical applications.

Keywords:

drug delivery exosome engineering exosomes extracellular vesicles gene delivery targeted delivery

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Last Updated: Oct 15, 2025

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Published on: December 5, 2018

Formulating and Characterizing an Exosome-based Dopamine Carrier System

Formulating and Characterizing an Exosome-based Dopamine Carrier System

Published on: April 4, 2022

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

Area of Science:

Biotechnology
Nanomedicine
Cell Biology

Background:

Exosomes are nanoparticles involved in intercellular communication.
They possess properties suitable for drug/gene delivery, including stability and low immunogenicity.
Current limitations include insufficient targeting and efficacy.

Purpose of the Study:

To review state-of-the-art designs of engineered exosomes for targeted delivery.
To discuss applications of advanced exosome-based systems.
To inspire further development of exosomal delivery systems for clinical use.

Main Methods:

Review of current literature on exosome engineering.
Analysis of expert opinions on exosome-based delivery systems.
Discussion of strategies to enhance exosome targeting and efficacy.

Main Results:

Engineered exosomes offer improved targeting and effectiveness.
Various approaches exist for modifying exosomes for specific applications.
Exosomes demonstrate potential for advanced drug and gene delivery.

Conclusions:

Engineered exosomes represent a promising platform for targeted cargo delivery.
Overcoming limitations in targeting and efficacy is crucial for clinical translation.
Further research can lead to practical exosomal delivery systems for therapeutic use.