Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

2.2K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
2.2K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

7.7K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
7.7K
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

748
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
748
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

1.0K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identifying Platelet Lipidomic Networks and Evaluating Machine-Learning Models to Identify Distinctive Features Between Chronic and Acute Coronary Syndrome.

Cells·2026
Same author

Routine Troponin I Assessment Enhances Risk Stratification in Hospitalized Patients with Seasonal Influenza.

Journal of clinical medicine·2026
Same author

Enhancing cardiac ablation efficacy with electroporation-assisted intracellular delivery of the ribosome-inactivating protein gelonin.

Bioelectrochemistry (Amsterdam, Netherlands)·2026
Same author

Targeting ACKR3/CXCR7 Enhances Platelet Anticoagulant Acylcarnitines and Modulates Procoagulant Function.

Blood·2026
Same author

The inflammatory fingerprint reveals immune cell populations associated with disease activity in cardiac sarcoidosis.

Clinical research in cardiology : official journal of the German Cardiac Society·2026
Same author

Platelet Casein Kinase 2α is a pivotal player in arterial thrombotic occlusion and post-ischemic myocardial remodeling.

Cardiovascular research·2026

Related Experiment Video

Updated: Oct 15, 2025

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

788

Platelets and COVID-19.

Anne-Katrin Rohlfing1, Dominik Rath1, Tobias Geisler1

  • 1Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls Universtität Tübingen, Tübingen, Germany.

Hamostaseologie
|October 25, 2021
PubMed
Summary

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes platelet hyperactivation, leading to severe thrombotic events. Thrombocytopenia in severe COVID-19 is linked to platelet apoptosis and consumption in microthrombi.

More Related Videos

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination
10:32

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination

Published on: August 24, 2015

13.8K
Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

732

Related Experiment Videos

Last Updated: Oct 15, 2025

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

788
Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination
10:32

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination

Published on: August 24, 2015

13.8K
Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

732

Area of Science:

  • Hematology
  • Virology
  • Immunology

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, with thrombotic events and cardiovascular complications observed.
  • Platelets are central to thrombus formation and have been implicated in SARS-CoV-2 pathogenesis, potentially carrying the virus and facilitating cell entry.
  • SARS-CoV-2 infection alters platelet counts, with thrombocytopenia characteristic of severe disease, linked to apoptosis and microthrombi formation.

Purpose of the Study:

  • To investigate the role of platelets in SARS-CoV-2 infection and associated thrombotic events.
  • To understand the mechanisms behind platelet hyperactivation and altered platelet counts in COVID-19 patients.

Main Methods:

  • Review of existing literature on SARS-CoV-2, COVID-19, platelets, and thrombosis.
  • Analysis of clinical data regarding platelet counts in mild versus severe COVID-19 cases.
  • Examination of proposed mechanisms for platelet activation and interaction with SARS-CoV-2.

Main Results:

  • Platelet hyperactivation, driven by factors like hypoxia and inflammation, contributes to excessive thrombus formation in COVID-19.
  • Platelets can carry SARS-CoV-2 and facilitate viral entry via furin cleavage of the spike protein.
  • Thrombocytopenia in severe COVID-19 results from platelet apoptosis and consumption in microthrombi.
  • Altered platelet chemokine profiles contribute to cytokine storms in severe COVID-19.

Conclusions:

  • Platelets play a critical role in the pathogenesis of severe COVID-19, contributing to both thrombosis and the inflammatory response.
  • Understanding platelet behavior in COVID-19 is crucial for developing targeted therapies to mitigate thrombotic complications and disease severity.