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Purification of Viral DNA for the Identification of Associated Viral and Cellular Proteins
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HSV-1 DNA Replication-Coordinated Regulation by Viral and Cellular Factors
Jessica E Packard1, Jill A Dembowski1
1Department of Biological Sciences, Duquesne University, Pittsburgh, PA 15282, USA.
Viruses
|October 26, 2021
Summary
Herpes simplex virus type 1 (HSV-1) DNA replication involves viral proteins and cellular processes. This review details how HSV-1 manipulates host cell proteins for successful viral infection.
Area of Science:
- Virology
- Molecular Biology
- Genetics
Background:
- Herpes simplex virus type 1 (HSV-1) DNA replication is crucial for its life cycle.
- Viral replication is tightly linked to cellular DNA damage response, repair, recombination, and gene transcription.
Purpose of the Study:
- To review the roles of viral and cellular proteins in HSV-1 DNA replication.
- To highlight HSV-1's strategies for adapting host cell proteins to aid infection.
Main Methods:
- Literature review of viral and cellular protein functions in HSV-1 DNA replication.
- Analysis of protein interactions and regulatory mechanisms.
Main Results:
- HSV-1 encodes essential replication proteins: UL9, ICP8, UL30, UL42, and UL5/UL8/UL52.
- HSV-1 utilizes accessory viral and cellular factors for replication coordination.
- The virus modifies and adapts host proteins to facilitate infection.
Conclusions:
- Understanding HSV-1 replication machinery and host interactions is key to combating viral infections.
- HSV-1 actively manipulates cellular processes for its own benefit.
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