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Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
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When infrared radiation is passed through a molecule, absorption occurs if the molecule's vibration leads to a substantial change in its bond dipole moment. Transitions between vibrational energy levels, typically corresponding to infrared frequencies (4000–400 cm−1), allow absorption if the vibration significantly alters the dipole moment, making the molecule infrared active. The molecular bonds have different stretching and bending vibrations, resulting in various peaks with...
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Pigmentation01:19

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Related Experiment Video

Updated: Oct 15, 2025

Method for the Assessment of Effects of a Range of Wavelengths and Intensities of Red/near-infrared Light Therapy on Oxidative Stress In Vitro
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Near-Infrared Light and Skin: Why Intensity Matters.

Daniel Barolet1

  • 1McGill University, Montreal, Québec, Canada.

Current Problems in Dermatology
|October 26, 2021
PubMed
Summary

Near-infrared (NIR) light, mimicking sunlight intensity, offers beneficial skin effects. Intensity, not just dose, is key for photobiomodulation, suggesting NIR is a solution for skin health.

Area of Science:

  • Photobiology
  • Dermatology
  • Biophysics

Background:

  • Near-infrared (NIR) light, a component of solar radiation, penetrates skin layers.
  • Past research linked high-intensity artificial NIR to detrimental skin effects.
  • Understanding NIR's biological impact requires considering light intensity and dose.

Purpose of the Study:

  • To re-evaluate the role of near-infrared (NIR) light in cutaneous biology.
  • To investigate the impact of NIR light intensity versus fluence on skin.
  • To determine if NIR light, at solar irradiance levels, offers beneficial effects.

Main Methods:

  • Review of photobiology principles, including the Arndt-Schulz curve.
  • Analysis of NIR light effects based on intensity and dose.

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  • Comparison of artificial light sources with natural sunlight NIR irradiance.

    • Main Results:

    • High-intensity artificial NIR can cause detrimental effects like MMP-1 upregulation.
    • Mimicking solar NIR intensity (30-35 mW/cm2) promotes beneficial cutaneous responses.
    • Photobiomodulation follows a biphasic dose curve, with optimal effects at physiological irradiance levels.

    Conclusions:

    • NIR light intensity is crucial for beneficial photobiomodulation, potentially more so than fluence.
    • Solar-level NIR intensity represents a "sweet spot" for positive skin effects.
    • NIR light may precondition skin against UVR, positioning it as a beneficial agent for skin health.