Related Experiment Video
Updated: Oct 15, 2025

Modeling Chemotherapy Resistant Leukemia In Vitro
Published on: February 9, 2016
Longer Time Intervals From Symptom Onset to Diagnosis Affect the Overall Survival in Children With Acute
Qingkai Dai1,2, Rui Liu1,2, Yuefang Wang1,2
1Department of Laboratory Medicine, West China Second University Hospital, Sichuan University.
Background:
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Early diagnosis and timely treatment are essential for effective cancer control and have been widely analyzed in childhood cancer. However, few studies have described the time to diagnosis and treatment in children with ALL. This study investigated delays in diagnosis and treatment initiation and their impact on survival.
Methods:
This retrospective cohort study included 419 patients 0 to 14 years old at a tertiary hospital between 2011 and 2015. The optimal cutoff values for delays were determined by X-tile software. The Kaplan-Meier method and Cox regression models were used to evaluate the impact of delays on survival.
Results:
The median diagnosis, treatment, and total delays were 21 (interquartile range [IQR]: 11-35), 4 (IQR: 2-7), and 26 (IQR: 16-43) days, respectively. The results of multivariate analyses showed that diagnosis delay, risk stratification, and minimal residual disease level were independent predictors for treatment outcome in childhood ALL.
Conclusions:
These findings suggested that a longer time to diagnosis negatively affected the clinical outcome of childhood ALL. Reducing the time to diagnosis could help to improve survival in these patients.
More Related Videos
10:49Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
09:57Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
Published on: March 5, 2018
Related Concept Videos
Cancer Survival Analysis
Assumptions of Survival Analysis
Introduction To Survival Analysis
The primary goal of survival analysis is to estimate survival time—the time...
Actuarial Approach
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
Pharmacokinetics in Pediatric Patients: Drug Excretion
Comparing the Survival Analysis of Two or More Groups