Related Experiment Video
Updated: Oct 15, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
The Association between Weight-related Variables and Postpartum Depressive Symptoms.
Meghan Baruth1, Rebecca A Schlaff2, Faith C LaFramboise3
1Meghan Baruth, Department of Health Science, Saginaw Valley State University, University Center, MI, United States;,
Higher pre-pregnancy BMI, current BMI, lower postpartum weight loss, and weight retention are linked to increased postpartum depressive symptoms (PPDS). Addressing weight concerns may help reduce PPDS risk.
Area of Science:
- Obstetrics and Gynecology
- Perinatal Mental Health
- Reproductive Health
Background:
- Postpartum depressive symptoms (PPDS) are a significant concern affecting maternal well-being.
- Weight-related factors are increasingly recognized as potential contributors to PPDS.
- Identifying these factors is crucial for targeted interventions.
Purpose of the Study:
- To investigate the association between various weight-related variables and the prevalence of PPDS.
- To determine which specific weight metrics are most strongly correlated with postpartum depression.
Main Methods:
- Online survey administered to 315 women within 12 months postpartum.
- Assessment of pre-pregnancy BMI, current BMI, weight loss, and weight retention.
- Regression models used to analyze associations between weight variables and PPDS scores.
Main Results:
- Higher pre-pregnancy BMI, current BMI, lower weight loss at 6 months postpartum, and substantial postpartum weight retention were significantly associated with increased PPDS.
- No significant association was found between gestational weight gain metrics and PPDS.
- Gestational weight gain and pre-pregnancy-to-postpartum BMI change did not correlate with PPDS.
Conclusions:
- Specific weight-related factors, including higher BMI and postpartum weight retention, are linked to a greater risk of PPDS.
- Interventions promoting healthy pre-conception weight and postpartum weight loss are warranted.
- Further research and clinical focus on weight management may aid in PPDS prevention and treatment.
Related Concept Videos
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Regression Toward the Mean
Anorexia Nervosa
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
Depression: Overview
Coefficient of Correlation
If you suspect a linear relationship between x and y, then r can measure how strong the linear relationship is.
What the VALUE of r tells us:
The value of r is always between –1 and +1: –1 ≤ r ≤ 1.
The size of the correlation r indicates the...
Depressive Disorders: MDD and Dysthymia

