Pulsed laser deposition of nanostructured bioactive glass and hydroxyapatite coatings: Microstructural and...

Bioactive coatings on metallic implants promote osseointegration between bone and implant interfaces. A suitable coating enhances the life span of the implant and reduces the requirement of revision surgery. The coating process needs to be optimized such that it does not alter the bioactivity of the material. To understand this, the biocompatibility of nanostructured bioactive glass and hydroxyapatite-coated Titanium substrate by pulsed laser deposition method is evaluated. Raman and IR spectroscopic techniques based on silica and phosphate functional groups mapping have confirmed homogeneity in coatings by pulse laser deposition method. Comparative studies on nanostructured bioactive glass and hydroxyapatite on titanium surface elaborated the significance of bioactivity, hemocompatibility, and cytocompatibility of the coated surface. Notably, both hydroxyapatite and bioactive glass show good hemocompatibility in powder form. Hemocompatibility and cytocompatibility results validate the enhanced sustenance for hydroxyapatite coating. These results signify the importance of the choice of coating methodology of bioceramics towards implant applications.