Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Picosecond laser-engineered osteon-inspired concentric micropatterns on titanium implants regulate cellular behaviour to facilitate osseointegration.

Materials today. Bio·2026
Same author

Correction: Vitamin D and curcumin-loaded PCL nanofibrous for engineering osteogenesis and immunomodulatory scaffold.

Frontiers in bioengineering and biotechnology·2025
Same author

Near-Infrared Responsive Biomimetic Titanate/TiO<sub>2-<i>X</i></sub> Heterostructure: A Therapeutic Strategy for Combating Implant-Associated Infection and Enhancing Osseointegration.

ACS applied materials & interfaces·2024
Same author

Preparation of co-electrospinning membrane loaded with simvastatin and substance P to accelerate bone regeneration by promoting cell homing, angiogenesis and osteogenesis.

Materials today. Bio·2023
Same author

Vitamin D and curcumin-loaded PCL nanofibrous for engineering osteogenesis and immunomodulatory scaffold.

Frontiers in bioengineering and biotechnology·2022
Same author

Multi-Omics Revealed the Protective Effects of Rhamnolipids in Lipopolysaccharide Challenged Broilers.

Frontiers in immunology·2022

Related Experiment Video

Updated: Oct 15, 2025

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

9.8K

JK-2 loaded electrospun membrane for promoting bone regeneration.

Abdullrahman M Al-Bishari1, Kendrick Hii Ru Yie1, Mohammed A Al-Baadani1

  • 1School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China.

Materials Science & Engineering. C, Materials for Biological Applications
|October 27, 2021
PubMed
Summary

This study developed polycaprolactone/gelatin scaffolds loaded with hydrogen sulfide (H2S) donor JK-2 for bone regeneration. The H2S-releasing scaffolds significantly enhanced bone healing in rabbit models.

Keywords:
Bone regenerationControlled releaseElectrospinningHydrogen sulfideJK-2

More Related Videos

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
09:32

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

10.0K
Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
11:20

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

7.8K

Related Experiment Videos

Last Updated: Oct 15, 2025

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

9.8K
Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
09:32

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

10.0K
Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
11:20

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

7.8K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Hydrogen sulfide (H2S) acts as a gasotransmitter and has therapeutic potential in various diseases.
  • H2S plays a role in bone formation and cellular signaling.
  • Developing effective bone regeneration strategies is crucial for treating bone defects.

Purpose of the Study:

  • To fabricate H2S-releasing nanofibrous scaffolds for bone healing.
  • To evaluate the efficacy of these scaffolds in a rabbit bone-defect model.
  • To investigate the role of H2S-loaded scaffolds in bone tissue engineering.

Main Methods:

  • Fabrication of polycaprolactone (PCL) and gelatin (Gel) nanofibrous scaffolds using electrospinning.
  • Loading scaffolds with JK-2, an H2S donor.
  • In vitro assessment of cell adhesion and proliferation.
  • In vivo implantation in a rabbit bone-defect model for 4 and 8 weeks.

Main Results:

  • PCL/Gel-JK-2 scaffolds showed enhanced cell adhesion and proliferation compared to PCL/Gel scaffolds.
  • In vivo studies demonstrated increased bone regeneration in the PCL/Gel-JK-2 group.
  • Significant improvements in bone healing were observed compared to control and unloaded scaffolds.

Conclusions:

  • PCL/Gel scaffolds loaded with the H2S donor JK-2 promote enhanced bone regeneration.
  • These H2S-releasing scaffolds show promise for bone tissue engineering applications.
  • Further consideration of JK-2 loaded scaffolds for bone regeneration is warranted.