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The Predictive Value of Hemocytometry Based on Peripheral Platelet-Related Parameters in Identifying the Causes of
1Department of Clinical Laboratory, The Affiliated Wuxi No.2 People's Hospital of Nanjing Medical University, Wuxi, 214001, People's Republic of China.
Insights
Platelet (PLT) count and mean platelet volume (MPV) are linked to febrile seizures (FSs) in children. Specific platelet markers may help differentiate FS types and predict recurrence risk.
Area of Science:
- Pediatric Neurology
- Hematology
- Clinical Biochemistry
Background:
- Febrile seizures (FSs) are common in childhood.
- Identifying predictive markers for FSs is crucial for clinical management.
Purpose of the Study:
- To investigate platelet-related parameters in children with FSs.
- To identify potential low-cost biomarkers for predicting FS occurrence and recurrence.
Main Methods:
- Retrospective analysis of whole blood cell counts from 79 patients with FSs, 82 with fever but no seizures (FC), and 81 healthy controls (HC).
- Comparison of platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and platelet-to-lymphocyte ratio (PLR) across groups.
Main Results:
- Children with FSs showed significantly lower PLT, MPV, hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and hematocrit (HCT) compared to FC and HC groups.
- Higher PLR was observed in FS and FC groups versus HC. Lower PLT and PLR were noted in the relapsed group.
- MCH, PLT, and MPV were strongly associated with FS occurrence, with MPV identified as a key protective factor.
Conclusions:
- Platelet count (PLT) and mean platelet volume (MPV) are significantly associated with the occurrence of febrile seizures.
- Platelet count (PLT) and platelet distribution width (PDW) may serve as simple indicators for differentiating FS types.
- Low platelet-to-lymphocyte ratio (PLR) could predict the risk of FS recurrence.
Objective:
To evaluate the outcome of platelet-related parameters in children with febrile seizures (FSs) and seek low-cost markers for the clinical prediction of FSs.
Methods:
A total of 79 patients with FSs (the FS group) who were hospitalized in our hospital were selected. Eighty-two patients with fever and without seizures (the FC group) and 81 healthy patients without fever (the HC group) were selected. The results of whole blood cell analysis were retrospectively analyzed.
Results:
The results of whole blood cell analysis showed that platelet (PLT) count, mean platelet volume (MPV), hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and hematocrit (HCT) levels in the FS group were significantly lower than in the FC and HC groups (P < 0.05). The platelet-to-lymphocyte ratio (PLR) in the FS and FC groups was significantly higher than in the HC group (P < 0.05), but there was no statistical difference between the FS and FC groups (P > 0.05). The PLT count in the CFS group was significantly lower than in the SFS group (P < 0.05). The PDW of the CFS group was higher compared with the SFS group (P < 0.05). The PLT count and PLR of the relapsed group were lower than those of the non-relapsed group (P < 0.05). The conducted linear regression analysis showed that MCH, PLT, and MPV were closely related to the occurrence of FSs. The binary logistic model showed that MPV was the most important protective factor related to FSs.
Conclusion:
PLT and MPV are closely related to the occurrence of FSs. PLT and PDW may be able to serve as simple yet effective laboratory indicators for distinguishing different types of FSs. Low PLR levels could be used to predict the risk of FS recurrence.
