Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

2.0K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
2.0K
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

103
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
103
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

71
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
71
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

172
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
172
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

84
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
84
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations01:26

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

97
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
97

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Case of BRASH Syndrome Presenting With Refractory Hyperkalemia Requiring Intermittent Hemodialysis.

Clinical case reports·2024
Same author

An Unusual Cause of Failure of Fiberoptic Intubation due to Continuous Suctioning: A Case Report.

Clinical case reports·2024
Same author

Pyopericardium progressing to cardiac tamponade in a patient with dengue fever.

IDCases·2024
Same author

Quantitative myelin water imaging using short TR adiabatic inversion recovery prepared echo-planar imaging (STAIR-EPI) sequence.

Frontiers in radiology·2023
Same author

Correlates of Myopathy in Diabetic Patients Taking Statins.

Cureus·2023
Same author

Chronic Obstructive Pulmonary Disease and Its Effect on Red Blood Cell Indices.

Cureus·2023

Related Experiment Video

Updated: Oct 15, 2025

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
09:35

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia

Published on: November 15, 2024

598

Hyperuricemia and Its Association With Ischemic Stroke.

Jaskamal Padda1, Khizer Khalid1, Sandeep Padda1

  • 1Internal Medicine, Jersey City (JC) Medical Center, Orlando, USA.

Cureus
|October 27, 2021
PubMed
Summary

Elevated serum uric acid (SUA) is linked to higher risks of cardiovascular disease and acute ischemic stroke (AIS). Research explores if lowering SUA with medications like allopurinol can reduce stroke incidence.

Keywords:
atherosclerotichypertensionhyperuricemiaischemic strokeserum uric acidurate lowering agents

More Related Videos

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

15.0K
Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model
05:32

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model

Published on: August 11, 2023

2.3K

Related Experiment Videos

Last Updated: Oct 15, 2025

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
09:35

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia

Published on: November 15, 2024

598
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

15.0K
Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model
05:32

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model

Published on: August 11, 2023

2.3K

Area of Science:

  • Cardiology
  • Neurology
  • Nephrology

Background:

  • Elevated serum uric acid (SUA) is increasingly recognized as a risk factor for cardiovascular (CV) diseases.
  • Acute ischemic stroke (AIS), a major cause of mortality, is a significant CV complication.
  • A dose-response relationship exists between high SUA levels and stroke risk.

Purpose of the Study:

  • To investigate serum uric acid as an independent risk factor for acute ischemic stroke.
  • To explore the biological mechanisms underlying the association between SUA and AIS.
  • To review the efficacy of antihyperuricemic drugs in mitigating AIS risk.

Main Methods:

  • A narrative review of full-text articles and abstracts.
  • Literature search conducted in PubMed and the Cochrane Library.
  • Appraisal of research findings on SUA, AIS, and antihyperuricemic therapies.

Main Results:

  • Studies confirm an association between elevated SUA and increased CV events, including AIS.
  • Allopurinol use in hyperuricemic patients has demonstrated a reduced risk of major CV events.
  • Emerging research suggests hyperuricemia's predictive role in AIS.

Conclusions:

  • Serum uric acid is a potential independent risk factor for acute ischemic stroke.
  • Antihyperuricemic medications may offer a therapeutic strategy to lower AIS risk.
  • Further investigation into SUA's role and treatment implications is warranted.