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Updated: Oct 15, 2025

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
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[Proper Perioperative Handling of Continuous Medication in Patients with Cardiac Comorbidities]

Tobias Ninke, Erich Kilger

    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS
    |October 27, 2021
    PubMed

    Insights

    Managing cardiac comorbidities like arterial hypertension (AHT), congestive heart failure (CHF), and coronary artery disease (CAD) is crucial for perioperative care. This review details current therapies and varying international guidelines for managing these conditions during surgery.

    Area of Science:

    • Cardiology
    • Anesthesiology
    • Internal Medicine

    Background:

    • Cardiac comorbidities, including arterial hypertension (AHT), congestive heart failure (CHF), and coronary artery disease (CAD), represent a significant health burden in Germany.
    • AHT affects one-third of adults, while CHF impacts approximately 2.5 million individuals. CAD prevalence is notable in older populations.
    • Optimal perioperative care necessitates a thorough understanding of managing these cardiac conditions.

    Purpose of the Study:

    • To review current medical therapies for prevalent cardiac comorbidities (AHT, CHF, CAD).
    • To analyze and compare international recommendations regarding the perioperative management of cardiac medications.
    • To provide a comprehensive resource for optimizing risk stratification and anesthesiological care.

    Main Methods:

    • Systematic literature review of current medical therapies for AHT, CHF, and CAD.
    • Comparative analysis of guidelines from various countries and medical societies on perioperative drug management.
    • Synthesis of evidence to inform clinical practice.

    Main Results:

    • Current medical therapies for AHT, CHF, and CAD are established, focusing on symptom management and disease progression.
    • Significant variability exists in recommendations for discontinuing or continuing cardiac medications perioperatively.
    • Lack of universal consensus complicates standardized patient care.

    Conclusions:

    • Effective management of cardiac comorbidities requires up-to-date knowledge of treatment strategies.
    • Understanding the nuances in perioperative drug management is essential for patient safety.
    • Further harmonization of international guidelines could improve perioperative outcomes for patients with cardiac conditions.

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