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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Related Experiment Video

Updated: Oct 15, 2025

Author Spotlight: Exploring ShiDuGao's Multi-Target Approach in Anus Eczema Treatment
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[Anal eczema].

Christoph F Dietrich1, Franz Hoch2

  • 1Beau Site, Salem und Permanence, Kliniken Hirslanden Bern.

Therapeutische Umschau. Revue Therapeutique
|October 27, 2021
PubMed
Summary

This article details various types of anal eczema, including allergic contact, atopic, irritative-toxic, and vulgar forms, alongside psoriasis inversa. It also covers perianal streptococcal dermatitis and candidiasis.

Area of Science:

  • Dermatology
  • Proctology

Background:

  • Perianal skin conditions encompass a range of inflammatory and infectious dermatoses.
  • Accurate diagnosis is crucial for effective management of anal and perianal conditions.

Purpose of the Study:

  • To describe and illustrate various forms of anal eczema and related perianal conditions.
  • To highlight key anamnestic and medical history information for differential diagnosis.

Main Methods:

  • Descriptive review of allergic contact eczema, atopic skin changes, irritative-toxic eczema, vulgar eczema, and psoriasis inversa.
  • Description of pathogen-related perianal streptococcal dermatitis (PSD) and perianal candidiasis.

Main Results:

  • Detailed descriptions and illustrations of the specified eczematous conditions and infections are provided.

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  • Emphasis on the importance of patient history in identifying causative factors.

    • Conclusions:

    • Understanding the clinical presentation and history of diverse perianal dermatoses is essential for accurate diagnosis.
    • This review serves as a guide for identifying and differentiating common anal and perianal skin conditions.