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Association between affective temperaments and severe coronary artery disease

Milán Vecsey-Nagy1, Bálint Szilveszter1, Márton Kolossváry1

  • 1MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.

Journal of Affective Disorders
|October 28, 2021
PubMed

Insights

Affective temperaments like hyperthymic and cyclothymic traits are linked to severe coronary artery disease (CAD). Understanding these temperaments may help identify individuals at higher risk for CAD.

Area of Science:

  • Cardiology
  • Psychiatry
  • Genetics

Background:

  • Affective temperaments are subclinical mood disorder traits.
  • Evidence suggests a role for affective temperaments in cardiovascular pathology.
  • This study investigated affective temperaments and severe coronary artery disease (CAD).

Purpose of the Study:

  • To analyze associations between affective temperaments and severe CAD.
  • To assess the predictive value of specific temperaments for CAD severity.
  • To identify potential biomarkers for cardiovascular risk stratification.

Main Methods:

  • 225 patients referred for coronary computed tomography angiography (CCTA) were included.
  • Patients completed the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire (TEMPS-A).
  • Logistic regression and ROC analysis identified predictors of severe CAD (≥70% stenosis).

Main Results:

  • Elevated hyperthymic temperament scores were associated with decreased odds of severe CAD (OR=0.92).
  • Dyslipidemia (OR=4.23) and cyclothymic temperament scores (OR=1.12) were positively associated with severe CAD.
  • Specific cutoffs for hyperthymic, cyclothymic, and irritable temperaments predicted severe CAD.

Conclusions:

  • Affective temperament evaluation may aid in identifying patients at elevated risk for severe CAD.
  • This could guide the need for timely coronary interventions.
  • Further research with longitudinal designs is warranted.
Abstract

Keywords:
Affective temperamentsCoronary CT angiographyCoronary artery disease

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