Quantitative splenic embolization possible: application of 8Spheres conformal microspheres in partial splenic...

Area of Science:

• Interventional Radiology
• Vascular Surgery

Background:

• Partial splenic embolization (PSE) is a procedure to reduce spleen size and function.
• 8Spheres are microspheres used for embolization.
• Investigating the safety and efficacy of 8Spheres in PSE is crucial.

Purpose of the Study:

• To evaluate the safety and efficacy of 8Spheres in partial splenic embolization.
• To determine if controlling the number of microspheres can accurately quantify splenic embolic volume.
• To compare outcomes between different microsphere sizes (300-500 um vs 500-700 um).

Main Methods:

• Retrospective analysis of 179 patients undergoing PSE.
• Patients divided into two groups based on microsphere size: 300-500 um (N=83) and 500-700 um (N=96).
• Comparison of spleen volume, infarct volume and rate, peripheral blood cell counts, and adverse events between groups.

Main Results:

• The 500-700 um group showed a significantly lower postoperative spleen volume (568.65 cm³ vs 753.82 cm³) and a higher spleen embolization rate (52.4% vs 41.1%).
• Both groups experienced significant increases in leukocytes and platelets post-PSE, with the 500-700 um group showing more stable increases at 1 and 3 months.
• The incidence of abdominal pain was higher in the 300-500 um group (86.7% vs 71.9%), while other adverse events and infections showed no significant difference.

Conclusions:

• Partial splenic embolization with 8Spheres is a safe and effective procedure.
• Using 500-700 um microspheres in PSE may lead to more stable peripheral blood cell count increases.
• Quantifying 8Spheres per vial allows for precise control of splenic embolic volume, enabling quantitative embolization.