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The Cohesin Complex and Its Interplay with Non-Coding RNAs
Merve Kuru-Schors1, Monika Haemmerle2, Tony Gutschner1
1Junior Research Group 'RNA Biology and Pathogenesis', Faculty of Medicine, Martin Luther University Halle-Wittenberg, 06120 Halle, Germany.
Non-Coding RNA
|October 28, 2021
Summary
The cohesin complex, crucial for DNA repair and gene regulation, interacts with non-coding RNAs. This review explores cohesin
Area of Science:
- Molecular Biology
- Genetics
- Epigenetics
Background:
- The cohesin complex is vital for sister chromatid cohesion, DNA repair, and chromosome architecture.
- Cohesin influences gene expression and organismal development across species.
- Its functions are modulated by protein interactions, post-translational modifications, and DNA modifications.
Purpose of the Study:
- To provide a condensed overview of cohesin complex architecture and function.
- To highlight the emerging role of non-coding RNAs in cohesin regulation.
- To explore the interplay between cohesin and both short and long non-coding RNAs.
Main Methods:
- Literature review of cohesin complex functions.
- Analysis of studies on non-coding RNA interactions with cohesin.
- Synthesis of current knowledge on cohesin-DNA and cohesin-RNA interactions.
Main Results:
- Cohesin's roles extend beyond sister chromatid cohesion to gene regulation and DNA repair.
- Non-coding RNAs (ncRNAs) are increasingly recognized as key regulators of cohesin.
- Both short and long ncRNAs influence cohesin's function and expression.
Conclusions:
- Cohesin is a multifunctional complex with critical roles in genome stability and gene expression.
- Non-coding RNAs represent a significant layer of regulation for the cohesin complex.
- Further research into cohesin-ncRNA interactions is essential for understanding gene regulation and development.
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