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Uveitis associated with cancer immunotherapy: long-term outcomes
Christine Fardeau1, Mehdi Bencheqroun1, Arielle Levy1
1Department of Ophthalmology, Reference Center for Rare Diseases, La Pitié-Salpêtrière Hospital, Paris-Sorbonne University, Paris, 75013, France.
Immunotherapy
|October 28, 2021
Summary
Cancer immunotherapy (CIT) can cause uveitis. Local corticosteroid injections are effective for managing CIT-associated uveitis, preserving vision and quality of life without compromising cancer treatment.
Area of Science:
- Ophthalmology
- Oncology
- Immunology
Background:
- Uveitis is a potential side effect of cancer immunotherapies (CIT).
- Long-term outcomes of CIT-associated uveitis require further investigation.
Purpose of the Study:
- To evaluate the long-term outcomes of uveitis associated with cancer immunotherapy.
- To assess the efficacy of various treatment regimens for CIT-associated uveitis.
Main Methods:
- Retrospective review of patients with CIT-associated uveitis.
- Analysis of treatment regimens including corticosteroids, rituximab, nivolumab, ipilimumab, vemurafenib, dabrafenib, trametinib, and ibritunib.
Main Results:
- Eight patients experienced uveitis, presenting as hypopyon, macular edema, or choroiditis.
- Favorable ophthalmological outcomes were achieved with various corticosteroid therapies.
- Treatment was effective regardless of whether CIT was continued or suspended.
Conclusions:
- Local corticosteroid injections combined with ongoing CIT show promise as a first-line treatment.
- This approach can help maintain patient quality of life.
- Effective management of uveitis may not compromise the vital prognosis of cancer patients.
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