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Association between hyperuricemia and hypertension: a case-control study
Talma Tallyane Dantas Bezerra1, Lucas Soares Bezerra2, Marcelo Antônio Oliveira Santos-Veloso2
1Universidade Federal de Pernambuco, Hospital das Clínicas, Serviço de Cardiologia - Recife (PB), Brazil.
This study found no independent link between high uric acid levels (hyperuricemia) and high blood pressure (systemic arterial hypertension). Age, diabetes, and kidney disease were associated with hypertension.
Area of Science:
- Cardiology
- Nephrology
- Metabolic Disorders
Background:
- Hyperuricemia is a condition of elevated uric acid levels in the blood.
- Systemic arterial hypertension is a prevalent cardiovascular risk factor.
- The relationship between hyperuricemia and hypertension requires further investigation.
Purpose of the Study:
- To investigate the association between hyperuricemia and systemic arterial hypertension.
- To identify independent risk factors for systemic arterial hypertension.
Main Methods:
- A case-control study included 75 adult patients, divided into hypertensive and non-hypertensive groups.
- Hyperuricemia was the primary independent variable, with adjustments for age, sex, lifestyle factors, and comorbidities.
- Logistic regression models were utilized for statistical analysis.
Main Results:
- Hyperuricemia was more frequent in hypertensive patients (18.9%, p=0.029).
- Univariate analysis showed a significant association between hyperuricemia and hypertension (OR 10.9, p=0.023).
- Multivariate analysis, adjusted for age, revealed no significant independent association (OR 8.5, p=0.070).
Conclusions:
- No independent association was found between hyperuricemia and systemic arterial hypertension.
- Systemic arterial hypertension was independently associated with diabetes mellitus, chronic kidney disease, and age.
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