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Evaluation of PathTezt™, a Liquid-Based Cytology System.

Nur Syuhada Mohd Nafis1, Anani Aila Mat Zin2

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Asian Pacific Journal of Cancer Prevention : APJCP
|October 29, 2021
PubMed
Summary

The PathTezt liquid-based Pap smear processor produces high-quality cervical cytology slides with excellent cellular fixation and morphology, proving effective for cervical cancer screening.

Keywords:
Cost-EffectivenessLiquid-based cervical smearPathTezt Processor

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Area of Science:

  • Cytopathology
  • Gynecologic Oncology
  • Medical Device Evaluation

Background:

  • Liquid-based preparation (LBP) cytology is widely adopted for cervical cancer screening due to its convenience and reliability.
  • The PathTezt™ is a second-generation LBP system employing a filter-based concentration technique.

Purpose of the Study:

  • To assess the cellular fixation, morphology, smear quality, and diagnostic interpretability of cervical cytology specimens processed by the PathTezt liquid-based processor.
  • Evaluate the performance of a novel liquid-based Pap smear system.

Main Methods:

  • 400 cervical Pap smear samples were processed using the PathTezt 2000 processor.
  • Slides were analyzed for sample adequacy, epithelial cell coverage, cellular distribution, obscuring factors, and cell fixation quality.

Main Results:

  • 95.25% of samples were satisfactory for evaluation.
  • Good cellular distribution (92%) and minimal inflammatory background (88.5%) were observed.
  • High-quality fixation and a 99% overall performance rate were achieved.

Conclusions:

  • The PathTezt liquid-based processor yields high-quality cervical cytology smears.
  • Despite being a newer system, PathTezt demonstrates cost-effectiveness and reliable results for cervical cancer screening.