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Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

Updated: Oct 15, 2025

Generation and Quantitative Analysis of Pulsed Low Frequency Ultrasound to Determine the Sonic Sensitivity of Untreated and Treated Neoplastic Cells
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Antibacterial Sonodynamic Therapy: Current Status and Future Perspectives.

Jayishnu Roy1, Vijayalakshmi Pandey2, Iti Gupta2

  • 1Discipline of Biological Engineering, Indian Institute of Technology (IIT) Gandhinagar, Gandhinagar, Gujarat 382355, India.

ACS Biomaterials Science & Engineering
|October 29, 2021
PubMed
Summary

Sonodynamic therapy (SDT) offers a novel approach to combat multidrug-resistant bacteria by using ultrasound to activate sensitizers, producing cell-killing reactive oxygen species (ROS). This therapy shows promise for treating infections where antibiotics fail.

Keywords:
cytotoxicitydelivery agentsreactive oxygen speciessonodynamic therapytherapeutic ultrasound

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Area of Science:

  • Biomedical Engineering
  • Antimicrobial Research
  • Therapeutic Ultrasound

Background:

  • Rising threat of multidrug-resistant bacteria necessitates novel therapeutic strategies.
  • Declining antibiotic discovery pipeline limits treatment options.
  • Physical therapies offer alternatives to conventional antibiotics.

Purpose of the Study:

  • To review recent advancements in antibacterial sonodynamic therapy (SDT).
  • To highlight the mechanisms, delivery systems, and clinical translation challenges of SDT.
  • To explore SDT as a viable alternative to traditional antibiotics.

Main Methods:

  • Review of literature on sonodynamic therapy for bacterial infections.
  • Analysis of biophysical and chemical mechanisms of SDT.
  • Investigation of novel delivery agents and ultrasound guidance strategies.

Main Results:

  • SDT utilizes ultrasound to activate sonosensitizers, generating reactive oxygen species (ROS) for targeted bacterial killing.
  • Current sonosensitizers often have poor bioavailability, driving research into nanoparticle-based delivery systems.
  • Ultrasound and image guidance are critical for effective SDT application.

Conclusions:

  • Antibacterial SDT presents a promising alternative to conventional antibiotics, particularly against resistant strains.
  • Development of effective sonosensitizers and targeted delivery systems is crucial for clinical success.
  • Further research and clinical trials are needed to overcome challenges in translating SDT to widespread use.