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Related Experiment Video

Updated: Oct 15, 2025

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
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Structure-function similarities in deep brain stimulation targets cross-species.

Max C Keuken1, Anneke Alkemade1, Niek Stevenson1

  • 1Integrative Model-based Cognitive Neuroscience Research Unit, University of Amsterdam, Nieuwe Achtergracht 129B, Postbus 15926, 1001 NK, Amsterdam, The Netherlands.

Neuroscience and Biobehavioral Reviews
|October 29, 2021
PubMed
Summary

Deep Brain Stimulation (DBS) effectively treats Parkinson's motor symptoms. A large meta-analysis shows that the function of most human DBS targets is conserved across species, aiding new treatment discoveries.

Keywords:
Cross-species comparisonDBSLDA topic modeling

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Last Updated: Oct 15, 2025

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Area of Science:

  • Neuroscience
  • Neurosurgery
  • Computational Biology

Background:

  • Deep Brain Stimulation (DBS) is a proven neurosurgical intervention for advanced Parkinson's disease motor symptoms.
  • The application of DBS is expanding to numerous brain regions for diverse neurological and neuropsychiatric disorders.
  • Validating new DBS targets relies on insights from animal models (rodent, primate).

Purpose of the Study:

  • To conduct a large-scale, automated meta-analysis comparing structure-function associations for 21 human DBS targets.
  • To investigate cross-species conservation of these associations between humans, rodents, and primates.
  • To identify potential shared brain networks underlying functional overlaps in DBS targets.

Main Methods:

  • Automated meta-analysis of neuroimaging and functional data.
  • Comparison of structure-function relationships for 21 subcortical DBS targets across species.
  • Identification of conserved and overlapping functional associations.

Main Results:

  • The majority of the 21 analyzed subcortical areas demonstrated conserved structure-function associations across species.
  • A subset of these structures exhibited overlapping functional associations.
  • Evidence suggests shared brain networks may explain targeting multiple areas for similar conditions.

Conclusions:

  • Structure-function relationships for most human DBS targets are conserved in animal models.
  • Overlapping functional associations point to shared neural networks, informing therapeutic target selection.
  • This cross-species comparative analysis provides a foundation for expanding DBS applications.