Related Experiment Video
Updated: Oct 15, 2025

Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment
Published on: December 6, 2024
Relationship between Post-traumatic Stress Disorder and subsequent myocardial infarction: a systematic review and
Murielle Jacquet-Smailovic1, Marie-Jo Brennsthul2, Ilona Denis2
1Centre Hospitalier du Pays d'Avesnes, Route de Haut-Lieu, 59363 Avesnes-sur-Helpe, France; Université de Lorraine, Département de psychologie de la santé, APEMAC/EPSAM UE 4360, Ile du Saulcy, 57000 Metz, France.
Background:
Each year, nearly 790.000 new cases of myocardial infarction (MI) are recorded in the United States. Better knowledge of the modifiable risk factors for this cardiovascular disease remains a major public health issue. In this perspective, the aim of this systematic review and meta-analysis was to estimate the relationship between post-traumatic stress disorder (PTSD) and risk of subsequent myocardial infarction (MI).
Methods:
A systematic review using PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analysis) guidelines was performed by searching four bibliographic databases (PubMed/Medline, PsycINFO, Science Direct and Proquest Dissertations and Theses).
Results:
A total of 14 articles were included. Nine of these included depression as a covariate. Among 13 studies (N = 848.903), the pooled HR for the magnitude of the relationship between PTSD and MI was 1.49 (95% CI 1.31-1.69) before adjustment for depression. The pooled HR estimate for the 9 depression-adjusted estimates (N = 814.441) was 1.32 (95% CI 1.12-1.56).
Limitations:
These results should be considered with caution because there is high heterogeneity between studies and possible publication bias; thus, further research is required to support these results.
Conclusions:
Further research is still needed to identify in more precise terms the mediating factors involved in the direct association between PTSD and the subsequent occurrence of ischemic heart disease.
More Related Videos
08:29Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
Published on: October 10, 2012
06:55An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
Related Concept Videos
Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
Post-traumatic Stress Disorder
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
Stress and Mental Health
Individuals with depression often experience challenges in both their personal and professional...
Acute Coronary Syndrome IV: Interprofessional Care
Coronary Artery Disease I: Introduction
Introduction to Stress and Lifestyle