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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
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Microbiome and paediatric gut diseases.

Konstantinos Gerasimidis1, Konstantinos Gkikas2, Christopher Stewart3

  • 1Human Nutrition, University of Glasgow, Glasgow, UK konstantinos.gerasimidis@glasgow.ac.uk.

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The gut microbiome is altered in pediatric gut diseases, but its role in pathogenesis and clinical practice is currently limited. Future research may unlock its diagnostic and therapeutic potential.

Keywords:
gastroenterologymicrobiology

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Area of Science:

  • Microbiology
  • Gastroenterology
  • Human Health

Background:

  • The human gut microbiome plays a critical role in maintaining overall health and homeostasis.
  • Alterations in the gut microbiome are implicated in the onset of various diseases, including non-communicable conditions.

Purpose of the Study:

  • To review the current evidence on the gut microbiome's role in the pathogenesis, outcomes, and management of pediatric gut diseases.
  • To assess the clinical implications of gut microbiome alterations in pediatric gastrointestinal conditions.

Main Methods:

  • Literature review of current evidence.
  • Analysis of studies on pediatric inflammatory bowel disease, celiac disease, intestinal failure, necrotizing enterocolitis, and irritable bowel syndrome.

Main Results:

  • The gut microbiome is demonstrably altered in various pediatric gut diseases.
  • However, current evidence provides limited insights into disease pathogenesis or clinical practice guidance.

Conclusions:

  • While the gut microbiome is altered in pediatric gut diseases, its direct clinical utility is currently minimal.
  • Future research may establish the microbiome for differential diagnosis, outcome prediction, and therapeutic targeting in pediatric gastroenterology.